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zoom RSS 栄養不良で毎年350万人の子どもが死亡

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 世界中の子どもの死亡原因の1/3は栄養不良による。
 胎内も含め低栄養により毎年350万人が死亡する。このうちの25%は母乳保育とビタミンAの補充により防止可能だろうとのLancetの報告。
 栄養不良の子供と妊婦の大多数はアフリカ・アジアの20ヶ国に住んでいる。乳児期の低栄養は不可逆性の障害を後にもたらす。
 亜鉛とビタミンAの補充と少なくとも生後6ヶ月までの母乳栄養の推奨で、死亡や後遺障害の1/4を減らせるだろう。しかし、国際社会の取り組みは散発的で機能不全である。
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Last Updated: Thursday, 17 January 2008, 01:39 GMT
Poor diets 'kill 3.5m children'
http://news.bbc.co.uk/2/hi/health/7192004.stm

画像African woman breastfeeding
Breastfeeding is key for baby nutrition

A third of child deaths globally are caused by poor nutrition, experts warn.

Around 3.5 million children die every year because of lack of food or poor quality food, a problem which starts in the womb, studies show.

Yet 25% of these deaths could be prevented with simple steps such as breastfeeding and vitamin A supplements, the Lancet reports.

The majority of undernourished children and pregnant women live in just 20 countries across Africa and Asia.

A special series in The Lancet also reported that poor nutrition in infancy leads to irreversible damage in later life.


Having an undernourished mother or infant causes irreversible damage even if nutrition improves later in childhood
Professor Caroline Fall, University of Southampton

Children who are under-nourished are likely to have shorter height and do less well at school, reducing their economic potential and perpetuating the poverty cycle, analysis found.

A separate study found "convincing evidence" for several measures which could have a big impact on reducing deaths if implemented properly.

Zinc and vitamin A supplements as well as encouraging women to breastfeed for at least six months would cut deaths and the loss of years through disability by a quarter, the researchers concluded.

But the international response to child deaths from poor nutrition has been "fragmented and dysfunctional", experts warned.

Global burden

Some children die because they simply do not have enough food.

But the issue is more complex for other children who suffer stunted growth and illnesses associated with deficiencies of vital vitamins and minerals.

The problem can be exacerbated by poor sanitation which spreads infectious diseases that cause diarrhoea.

Professor Zulfiqar Bhutta, Department of Paediatrics and Child Health at Aga Khan University in Pakistan estimated that 1.4 million child deaths annually are caused by a lack of breastfeeding.

In Africa, Asia, Latin America and the Caribbean less than a third of children under the age of six months are breastfed exclusively, he said.

Professor Caroline Fall, from the University of Southampton, who carried out the research into long-term effects of poor nutrition said: "Having an undernourished mother or infant causes irreversible damage even if nutrition improves later in childhood - you don't get the chance to recover much".

Dr Bruce Cogill, a nutrition expert at Unicef, said the global burden caused by under-nutrition was "a call to action".

He added that nutrition programmes were "woefully under-resourced" compared to other global health issues, such as Aids.

Professor Simon Cousens, from the London School of Hygiene and Tropical Medicine said the period from conception until 24 months of age was most crucial.

"Countries with a high prevalence of under-nutrition must decide which interventions should be given the highest priority, and ensure their active implementation."

Save the Children said if trends in Africa continued, 3.7 million more children will be suffering from malnutrition in 2015 than today.

David Mepham, director of policy at the charity said: "Children who are malnourished suffer cognitive impairment, affecting their capacity to learn, and they have much weaker immune systems, making them more vulnerable to disease and early death."

He called for the UK and EU governments to do more to tackle the problem.

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The Lancet 2008; 371:179
DOI:10.1016/S0140-6736(07)61869-8
Comment

Maternal and child undernutrition: an urgent opportunity

Nutrition is a desperately neglected aspect of maternal, newborn, and child health. The reasons for this neglect are understandable but not justifiable. When one considers specific actions to improve maternal and child survival, one is drawn to particular interventions―vaccination, oral rehydration therapy, and the treatment of infection and haemorrhage. In recent years, this portfolio of responses has broadened to embrace the health system―human resources, financing, and stewardship. Somehow, nutrition has slipped through the gap.

And yet we know that nutrition is a major risk factor for disease.1 What public-health experts and policymakers have not done is to gather the evidence about the importance of maternal and child nutrition, catalogue the long-term effects of undernutrition on development and health, identify proven interventions to reduce undernutrition, and call for national and international action to improve nutrition for mothers and children. The five-part Series on maternal and child undernutrition, launched this week by The Lancet, aims to fill this gap in global public health and policy action.

The key messages of the Series, which has been written by an independent team of public-health scientists led by Robert Black, Zulfiqar Bhutta, Jennifer Bryce, Saul Morris, and Cesar Victora, are critically important for all those concerned with the health and wellbeing of women and children. Undernutrition is the largely preventable cause of over a third―3·5 million―of all child deaths. Stunting, severe wasting, and intrauterine growth restriction are among the most important problems. There is a golden interval for intervention: from pregnancy to 2 years of age. After age 2 years, undernutrition will have caused irreversible damage for future development towards adulthood.

Incredibly, four-fifths of undernourished children live in just 20 countries across four regions―Africa, Asia, western Pacific, and the middle East. These are the priority nations for action. In terms of under-5 mortality rates, the most immediate needs are for Afghanistan, Democratic Republic of Congo, Nigeria, Ethiopia, Uganda, Tanzania, Madagascar, Kenya, Yemen, and Burma. In order of population size, and excluding the countries with highest mortality rates, the ranking is different: India, Indonesia, Pakistan, Bangladesh, Vietnam, Philippines, Egypt, South Africa, Sudan, and Nepal.

As this Series shows so clearly, there are proven effective interventions to reduce stunting and micronutrient deficiencies. According to strict criteria around admissible evidence, breastfeeding counselling, vitamin A supplementation, and zinc fortification have the greatest benefits. Attention to maternal nutrition through adequate dietary intake in pregnancy and supplementation with iron, folic acid, and possibly other micronutrients and calcium are likely to provide value. But these interventions need additional programmatic experience about how to achieve full coverage.

There is no magic technological bullet to solve the problem of undernutrition. Long-term investments in the role of women as full and equal citizens―through education, economic, social, and political empowerment―will be the only way to deliver sustainable improvements in maternal and child nutrition, and in the health of women and children more generally.

The compelling logic of this scientific evidence is that governments need national plans to scale-up nutrition interventions, systems to monitor and evaluate those plans, and laws and policies to enhance the rights and status of women and children. Although complex and fraught with political disagreement, none of these solutions are separable from global treaties and negotiations over trade, agriculture, and poverty reduction. This latest Lancet Series concludes, not surprisingly perhaps, that the international nutrition system is broken. Leadership is absent, resources are too few, capacity is fragile, and emergency response systems are fragmentary. New governance arrangements are urgently needed. An agency, donor, or political leader needs to step up to this challenge. There is a fabulous opportunity right now for someone to do so. But who?
References

1. Lopez AD, Mathers CD, Ezzati M, Jamison DT, Murray CJL. Global and regional burden of disease and risk factors, 2001: systematic analysis of population health data. Lancet 2006; 367: 1747-1757.

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栄養素「亜鉛」は免疫のシグナル
http://www.riken.jp/r-world/info/release/press/2006/060807/detail.html
- 免疫系の活性化に細胞内亜鉛濃度が関与 -
* 亜鉛が免疫応答を制御
* 亜鉛がシグナル伝達分子として作用する
* 免疫の新領域を開拓
 亜鉛は身体に必須な微量金属の一つです。欠乏すると成長障害や免疫不全、味覚障害などの異常が生じることが知られています。また、亜鉛が存在しなければ機能しないタンパク質は体内に300種類も存在し、亜鉛は体を構成する必須な成分とも考えられてきました。しかし、亜鉛の濃度変化が細胞の増殖、分化や機能を調節する可能性については、これまで、全く考えられてきませんでした。
 今回、研究グループは、細胞内の亜鉛濃度を連続的に観測し、免疫細胞が刺激を受けて活性化する過程で、細胞内の亜鉛濃度が変化することを初めて発見しました。さらに、この亜鉛濃度の変化は、体内の免疫応答を活性化させるためのシグナルとして働いていることや、亜鉛濃度の調節は、細胞内の亜鉛輸送タンパク質が行なっていることを明らかにしました。
 免疫系は様々な免疫細胞が協力して、細菌やウイルスの感染防御、がん化した細胞の駆逐などを行なっています。現在、免疫細胞の機能を制御することによって、がんワクチンなどの次世代ワクチンの開発、アレルギーや自己免疫疾患といった疾病に対する新しい治療法の開発が行なわれています。今回の発見は、細胞内の亜鉛濃度を人為的に調節することによって、免疫応答をコントロールできるという新しい可能性を示すものです。さらに、亜鉛によって活性化するタンパク質は免疫細胞のみならず生体内のすべての細胞群に存在することから、亜鉛がシグナルを伝達するという今回の発見は、広く生命科学全体に重要な示唆を与えるものと考えられます。

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栄養不良で毎年350万人の子どもが死亡 医師の一分/BIGLOBEウェブリブログ
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