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zoom RSS 硫酸マグネシウムが未熟児の脳性麻痺のリスクを軽減

<<   作成日時 : 2008/02/01 22:38   >>

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 アラバマ大の最新の研究により、出産直前に妊婦に硫酸マグネシウムを与えると、未熟児の脳性麻痺の危険性が半減されるという。
 エプソム塩として知られる化合物が妊娠に関連した高血圧と早産予防に既に使用されている。はっきりとはわかっていないが、新生児の脳血管を拡張すると考えられる。
 在胎24〜31週の妊婦2241人について(37週より前に生まれる場合に未熟児という)、プラセーボ群との比較試験を行い、2歳時に脳性麻痺の評価テストを行った。中等度から重度の脳性麻痺の割合がプラセーボ群4%にたいして2%と半分であった。死亡数は両群ともほぼ同じだった。
 副作用が問題となるが、硫酸マグネシウムは鎮静作用があり、母子共に眠くなる。
 同時に発表された別の研究で、葉酸を妊娠1年前から服用すると未熟児出生を50-70%減らす可能性があるという。葉酸は二分脊椎のような脳脊髄の異常を予防するために妊娠可能な女性への服用が推奨されている。
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Compound Cuts Cerebral Palsy in Preemies
Study: Giving Moms Magnesium Sulfate Cuts Risk of Cerebral Palsy in Extreme Premature Babies
http://abcnews.go.com/Health/ReproductiveHealth/wireStory?id=4221441
NEW YORK Jan 31, 2008 (AP)
画像Doctors can cut the risk of cerebral palsy in half for very premature babies by giving their mothers magnesium sulfate just before they give birth, new research shows.
The mineral compound, also known as Epsom salts, is already used to treat preganancy-related high blood pressure and to stop early labor. Doctors should consider giving it to women about to deliver an extremely preterm infant, said one of the researchers, Dr. John Thorp of the University of North Carolina.
"It's cheap. It's readily available. It doesn't harm anybody. I think it will be widely adopted," said Thorp.
The research was led by Dr. Dwight Rouse at the University of Alabama at Birmingham, who was presenting it Thursday at a meeting of the Society for Maternal-Fetal Medicine in Dallas.
Cerebral palsy is a serious complication of premature birth. It's caused by damage to the part of the brain that controls movement and results in poor muscle control and coordination.
Thorp said it isn't clear how magnesium sulfate works, but it is thought to open up blood vessels in the newborn's brain.
In the government-funded study, researchers gave an infusion of magnesium sulfate to women about to give birth to a premature baby to see if it would reduce the risk of cerebral palsy. Enrolled in the study were 2,241 women who were 24 to 31 weeks pregnant. Infants born before 37 weeks are considered premature.
Most of the women were in early labor because their water broke. They were given either the compound or a fake solution. The infants were examined for signs of cerebral palsy at birth and over the next two years.
Of the babies who survived, moderate or severe cerebral palsy occurred in about 2 percent of those in the treatment group compared to about 4 percent of those whose mothers didn't get the compound.
The number of infants who died was about the same in both groups.
"Cerebral palsy is not a terribly common outcome in preterm infants but when it does happen, it's devastating," said Dr. Judy Aschner, chief of neonatology at Vanderbilt Children's Hospital, who was not involved in the study.
She said doctors will want to see the details on side effects when the study is published before making any changes in the care of mothers in preterm labor. Magnesium sulfate acts like a sedative and can make moms and infants groggy and sleepy, she said.
"This is a really important study and potentially one that could change general practice," Aschner said.
In another study presented at the conference, researchers found that women who take folic acid for at least a year before they become pregnant may reduce their chances of early premature birth by 50 to 70 percent. Taking folic acid is already recommended for women of childbearing age to prevent birth defects to the brain and spinal cord, such as spina bifada.
"Here we have an added reason to motivate women to take it and to take it early in their lives," said Dr. Alan Fleischman, medical director of the March of Dimes. The group was giving the research an award at the Dallas meeting.
On the Net:
March of Dimes: http://www.marchofdimes.com
Copyright 2008 The Associated Press. All rights reserved. This material may not be published, broadcast, rewritten, or redistributed.

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スイスの新生児の名前ランキング
スイスの赤ちゃんの名前ランキングが毎年発表されるの知ってた??2006年の統計によると、女の子は、「Anna」、男の子は、「Luca」が一番人気だったんだって ?でも、これは、ドイツ語圏での話。フランス語圏では、女の子は、「Lea」、男の子は、「Samuel」が人気だったそうだよイタリア語圏では、どうだったんだろうね。 ...続きを見る
スイス滞在10年の日本人が綴る[必見]ス...
2008/02/02 17:46

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硫酸マグネシウムが未熟児の脳性麻痺のリスクを軽減 医師の一分/BIGLOBEウェブリブログ
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