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<<   作成日時 : 2009/09/16 02:24   >>

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 動物でガンをおこすウイルスが人の前立腺癌に関連しているとしたことが証明された。
 ユタ大・コロンビア大の医学研究者は200個の前立腺癌のうち27%でウイルスを発見した。それはより悪性の腫瘍と関連し、癌がない前立腺ではわずか6%に発見されたにすぎなかったと言う。この発見はワクチン治療の可能性を強くする。以前の研究で、宿主と異なる種の細胞で増殖するネズミ白血病ウイルスXRMVが前立腺癌と関連するとわかっていた。
 XMRVは、自身のDNAのコピーを、感染させる細胞の染色体に挿入することによって働くHIVのようなレトロウイルスである。これが細胞増殖を制御する遺伝子の近くにおこると細胞の正常発達を混乱させられる。
 このウイルスの特徴の一つがアンドロゲンに反応する要素を持つと言うことである。
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Page last updated at 23:44 GMT, Monday, 7 September 2009 00:44 UK
Virus linked to prostate tumours
http://news.bbc.co.uk/2/hi/health/8241835.stm

画像A prostate cancer cell
Prostate cancer is a major killer

Scientists have produced compelling evidence that a virus known to cause cancer in animals is linked to prostate cancer in humans.

The researchers from the University of Utah and Columbia University medical schools found the virus in 27% of the 200 cancerous prostates they looked at.

They say it was associated with more aggressive tumours and found in only 6% of non-cancerous prostates.

The finding raises the prospect of one day producing a vaccine.

Previous research has linked XRMV (Xenotropic murine leukaemia virus) to prostate cancer but not in such an aggressive way.

Retrovirus

XMRV is a retrovirus like HIV which works by inserting a copy of its own DNA into the chromosomes of a cell they infect.

We still don't know that this virus causes cancer in people, but that is an important question we are going to investigate.
Dr Ila Singh, University of Utah

Where this occurs next to a gene that regulates cell growth it can disrupt the normal development of the cell.

XMRV is known to cause leukaemia and other tumours in animals.

Dr Ila Singh, who led the study from the pathology department at the University of Utah, said: "We still don't know that this virus causes cancer in people, but that is an important question we are going to investigate.

"One of the things peculiar about this virus is that it has an androgen response element - it grows better in the presence of testosterone and possibly other steroid hormones.

PROSTATE CANCER FACTS
Most common cancer in men in UK
10,000 die each year
Most cases are in those aged 70-74
Higher rates in most deprived populations
Source: Cancer Research UK

"This is particularly interesting because if we can prove that it responds to oestrogen it could have a role in other cancers.

"We are already looking at the bodies of 100 women and 100 men, who died from other causes, to see if any other organs carry the virus."

Risk factor

Dr Helen Rippon, Head of Research Management at The Prostate Cancer Charity, said the research was intriguing but posed several key questions about the role the infection plays in prostate cancer.

It is critically important to identify key triggers of prostate cancer to improve early detection
Dr Helen Rippon, Prostate Cancer Charity

She said: "Around the world, extensive work is being undertaken to identify risk factors for prostate cancer which will enable treatments and tests for the disease to be refined.

"It is critically important to identify key triggers of prostate cancer to improve early detection of the disease in men with potentially life threatening prostate cancer."

Dr Chris Parker, Cancer Research UK's prostate cancer expert at the Institute of Cancer Research said: "This exciting study raises the possibility that the virus might contribute to the development of some prostate cancers.

"In the future, if it turns out to be true, then we could speculate about the possibility of vaccination to protect against prostate cancer, similar to the approach now used to prevent cervical cancer."

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