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zoom RSS コーヒーのカフェインは慢性C型肝炎による肝硬変を軽減

<<   作成日時 : 2010/01/11 23:25   >>

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画像 新たな研究で、コーヒーのカフェインは慢性C型肝炎による肝線維化のリスクを軽減するとわかった。
 平均51才の177人の患者のカフェイン摂取を2年間追跡したところ、1日308mg以上のカフェインを摂取する人は肝臓線維化が軽かったという。毎日2.25杯のコーヒーと等しい。カフェイン67mg(カップ1/2のコーヒー相当)摂取増加で14%リスクが減少する。
 お茶やカフェイン添加ソフトドリンク・カフェイン錠剤などは同じカフェインでも同様な効果は見られない。
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紅茶とコーヒーを飲む人は糖尿病になりにくい?
http://kurie.at.webry.info/201001/article_1.html
コーヒーが痴呆症のリスク軽減に関連
http://kurie.at.webry.info/200901/article_41.html
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Coffee Cuts Liver Scarring in Hepatitis C
Other sources of caffeine don't have same effect, study shows
-- Robert Preidt
http://health.msn.com/nutrition/articlepage.aspx?cp-documentid=100252293

Other sources of caffeine don't have same effect, study shows.

FRIDAY, Jan. 8 (HealthDay News) -- Caffeine in coffee reduces the severity of liver fibrosis in patients with chronic hepatitis C virus, a new study has found.

Liver fibrosis (scarring of the liver) is the second stage of liver disease during which liver function declines because of accumulated connective tissue.

The new U.S. National Institutes of Health study included 177 patients, mean age 51, whose daily consumption of caffeine from food and beverages was tracked for two years.

Patients who consumed more than 308 milligrams of caffeine from coffee per day had milder liver fibrosis than other patients. The daily amount of caffeine intake found to be beneficial is equivalent to 2.25 cups of regular coffee. For each 67-milligram increase in caffeine consumption (about one half cup of coffee), there was a 14 percent decrease in the odds of advanced fibrosis for patients with hepatitis C virus.

Other sources of caffeine -- such as soft drinks, tea, caffeine-fortified drinks and caffeine pills -- didn't have the same helpful effect, according to the study published in the January issue of the journal Hepatology.

The researchers said further research is needed to determine whether the protective effects of coffee/caffeine increase at levels beyond normal daily intake.

More information

The U.S. Centers for Disease Control and Prevention has more about hepatitis C.
SOURCE: Hepatology, news release, Jan. 5, 2010

Copyright (c) 2009 ScoutNews, LLC. All rights reserved.

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Increased caffeine consumption is associated with reduced hepatic fibrosis
Apurva A. Modi 1, Jordan J. Feld 1 2, Yoon Park 1, David E. Kleiner 3, James E. Everhart 4, T. Jake Liang 1, Jay H. Hoofnagle 1 *§
1Liver Diseases Branch, National Institutes of Diabetes and Digestive and Kidney Diseases (NIDDK), National Institutes of Health (NIH), Bethesda, MD
2Toronto Western Hospital Liver Clinic, Division of Gastroenterology, University of Toronto, Toronto, Canada
3National Cancer Institute, NIH, Bethesda, MD
4Division of Digestive Diseases and Nutrition, NIDDK, NIH, Bethesda, MD
email: Jay H. Hoofnagle (HoofnagleJ@extra.niddk.nih.gov)

*Correspondence to Jay H. Hoofnagle, Director, Liver Disease Research Branch, Division of Digestive Diseases and Nutrition, NIDDK, NIH, Building 31 Room 9A27, Bethesda, MD 20892
Potential conflict of interest: Nothing to report.
These authors contributed equally to the study.
§fax: 301-480-7926

Abstract
Although coffee consumption has been associated with reduced frequency of liver disease, it is unclear whether the effect is from coffee or caffeine and whether there is an effect on hepatic fibrosis specifically. This study was undertaken to use a food-frequency instrument for dietary caffeine consumption to evaluate the relationship between caffeine intake and liver fibrosis. Patients undergoing liver biopsy completed a detailed caffeine questionnaire on three occasions over a 6-month period. Caffeine intake was compared between patients with mild and advanced liver fibrosis (bridging fibrosis/cirrhosis). Logistic regression was used to evaluate the association between caffeine consumption and hepatic fibrosis. One hundred seventy-seven patients (99 male, 104 white, 121 with chronic hepatitis C virus [HCV] infection) undergoing liver biopsy completed the caffeine questionnaire on up to three occasions. Results from repeated questionnaires were consistent. Daily caffeine consumption above the 75th percentile for the cohort (308 mg = approximately 2.25 cups of coffee equivalents) was associated with reduced liver fibrosis (odds ratio [OR], 0.33; 95% confidence interval [CI], 0.14-0.80; P = 0.015) and the protective association persisted after controlling for age, sex, race, liver disease, body mass index, and alcohol intake in all patients (OR, 0.25; 95% CI, 0.09-0.67; P = 0.006), as well as the subset with HCV infection (OR, 0.19; 95% CI, 0.05-0.66; P = 0.009). Despite a modest trend, consumption of caffeine from sources other than coffee or of decaffeinated coffee was not associated with reduced liver fibrosis. A reliable tool for measurement of caffeine consumption demonstrated that caffeine consumption, particularly from regular coffee, above a threshold of approximately 2 coffee-cup equivalents per day, was associated with less severe hepatic fibrosis. (HEPATOLOGY 2010;51:201-209.)
Received: 24 April 2009; Accepted: 21 August 2009

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