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<<   作成日時 : 2010/01/26 19:50   >>

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 ビタミンD不足が大腸ガンのリスクに
 血液中のビタミンDが低いと大腸ガンになりやすいとのフランスからの報告。血液中の高い人は低い人に比べて40%リスクが低いという。
 ビタミンDは細胞や骨のカルシウムレベルを調節しているが、細胞の増殖や死を調節したり血管造成を抑えることでガンの増殖にも関係しているという証拠も出てきている。
 食事中のビタミンD摂取でみた疫学的な調査でははっきりした結果は出ていない。欧州での52万人のボランティアの調査から大腸ガンになった1,248人と対照群1,248人を比較した。
 血中ビタミンDの高い方の1/5に比べて低い方の1/5は有意にガンになりやすかった。直腸ではなくて結腸がんでその傾向がみられた。
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10代での肥満が多発性硬化症のリスクに
http://kurie.at.webry.info/200911/article_16.html
ビタミンDが多発性硬化症関連遺伝子の制御を補助する
http://kurie.at.webry.info/200902/article_19.html
ビタミンDの低下とパーキンソン病
http://kurie.at.webry.info/200810/article_32.html
小児のビタミンD不足
http://kurie.at.webry.info/200806/article_8.html
ビタミンDが乳がんを予防する可能性
http://kurie.at.webry.info/200805/article_35.html
乳がん発症率 日光とビタミンDが関連
http://kurie.at.webry.info/200805/article_52.html
子どものビタミンD摂取量を2倍に/米国
http://kurie.at.webry.info/200810/article_31.html
ビタミンDが心臓発作を予防
http://kurie.at.webry.info/200806/article_19.html
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Low Vitamin D Linked to Colon Cancer
Study: People With Low Levels of Vitamin D Are More Likely to Get Colon Cancer
By MICHAEL SMITH
MedPage TodayStaff Writer
Jan. 22, 2010
http://abcnews.go.com/Health/WellnessNews/low-vitamin-levels-linked-colon-cancer-study-finds/story?id=9636657

画像Low Vitamin D Linked to Colon Cancer
Low levels of circulating vitamin D are associated with a greater risk of colorectal cancer, European researchers say.
(Taxi/Getty Images)

A case-control study found that people in the top fifth of vitamin D levels had 40 percent lower risk for colorectal cancer than those in the bottom fifth, according to Mazda Jenab of the International Agency for Research on Cancer in Lyon, France, and colleagues.

But more research is needed to see if increasing circulating vitamin D can effectively reduce the risk of the disease, they concluded online in the British Medical Journal.

The main role of vitamin D is to maintain calcium levels in cells and bone metabolism, the researchers noted in the journal. But there is some evidence that it may also play a role in cancer control by modulating cell growth and death and by reducing the development of blood vessels to support tumor tissue.

Unfortunately, they said, epidemiological evidence -- mostly based on counting people's dietary intake of vitamin D rather than taking blood circulating levels -- is inconclusive.

To fill the gap, they turned to the European Prospective Investigation into Cancer and Nutrition (EPIC) study, which is prospectively following 520,000 volunteers from 10 European countries.

Jenab and colleagues compared 1,248 people who developed colorectal cancer after enrollment with 1,248 controls who were disease-free.

Dietary and lifestyle data were obtained from questionnaires and researchers measured circulating vitamin D concentrations.

The researchers found:

There was a linear trend for colorectal cancer. Those in the lower fifths of vitamin D levels significantly more likely to get the disease than those in higher fifths.

The same trend was seen for colon cancer but not rectal cancer.

Compared with volunteers with a mid-level concentrations, those in the lowest fifth had a 32 percent increased risk of colorectal cancer.

Higher concentrations were associated with lower risk.

The vitamin D concentration was associated with lower colorectal risk in a dose-response manner, the researchers reported.

The study's strengths include its large size and prospective (following a group of people before any got sick) design, the researchers said. Also levels of circulating vitamin D before a diagnosis of cancer were available for all participants.

On the other hand, follow-up was relatively short, which may mean that some participants with disease already had the illness at the time the samples were taken.

In addition, the study did not control for colorectal screening; however, the investigators said this is not routinely performed in Europe.

----------------------------------------------------
Published 21 January 2010, doi:10.1136/bmj.b5500
Cite this as: BMJ 2010;340:b5500
Research
Association between pre-diagnostic circulating vitamin D concentration and risk of colorectal cancer in European populations:a nested case-control study

Mazda Jenab, International Agency for Research on Cancer (IARC-WHO), Lyon, France

Objective To examine the association between pre-diagnostic circulating vitamin D concentration, dietary intake of vitamin D and calcium, and the risk of colorectal cancer in European populations.

Design Nested case-control study.

Setting The study was conducted within the EPIC study, a cohort of more than 520 000 participants from 10 western European countries.

Participants 1248 cases of incident colorectal cancer, which developed after enrolment into the cohort, were matched to 1248 controls

Main outcome measures Circulating vitamin D concentration (25-hydroxy-vitamin-D, 25-(OH)D) was measured by enzyme immunoassay. Dietary and lifestyle data were obtained from questionnaires. Incidence rate ratios and 95% confidence intervals for the risk of colorectal cancer by 25-(OH)D concentration and levels of dietary calcium and vitamin D intake were estimated from multivariate conditional logistic regression models, with adjustment for potential dietary and other confounders.

Results 25-(OH)D concentration showed a strong inverse linear dose-response association with risk of colorectal cancer (P for trend <0.001). Compared with a pre-defined mid-level concentration of 25-(OH)D (50.0-75.0 nmol/l), lower levels were associated with higher colorectal cancer risk (<25.0 nmol/l: incidence rate ratio 1.32 (95% confidence interval 0.87 to 2.01); 25.0-49.9 nmol/l: 1.28 (1.05 to 1.56), and higher concentrations associated with lower risk (75.0-99.9 nmol/l: 0.88 (0.68 to 1.13); ?100.0 nmol/l: 0.77 (0.56 to 1.06)). In analyses by quintile of 25-(OH)D concentration, patients in the highest quintile had a 40% lower risk of colorectal cancer than did those in the lowest quintile (P<0.001). Subgroup analyses showed a strong association for colon but not rectal cancer (P for heterogeneity=0.048). Greater dietary intake of calcium was associated with a lower colorectal cancer risk. Dietary vitamin D was not associated with disease risk. Findings did not vary by sex and were not altered by corrections for season or month of blood donation.

Conclusions The results of this large observational study indicate a strong inverse association between levels of pre-diagnostic 25-(OH)D concentration and risk of colorectal cancer in western European populations. Further randomised trials are needed to assess whether increases in circulating 25-(OH)D concentration can effectively decrease the risk of colorectal cancer.

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