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zoom RSS オメガ3脂肪酸で精神疾患を予防する

<<   作成日時 : 2010/02/03 20:22   >>

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 ハイリスクの人が毎日魚油カプセルを服用すると精神疾患を予防できるという。
 3ヶ月補充すると統合失調症などの発病を1/4に減らし、薬物と同等の効果が得られる。オメガ3がその効果を脳に及ぼしている。
 向精神薬は強力だが副作用の可能性があり、服用を止めてしまう人もいる。
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オメガ3脂肪酸で老化防止/心臓病患者で調査
http://kurie.at.webry.info/201001/article_26.html
オメガ3脂肪酸が加齢黄斑変性症に効果
http://kurie.at.webry.info/200906/article_13.html
オメガ3脂肪酸の抗炎症作用
http://kurie.at.webry.info/200711/article_41.html
EPA/DHA 大量療法が ADHD注意欠陥多動性障害に効果あり
http://kurie.at.webry.info/200708/article_31.html
肝油が うつ病に効果
http://kurie.at.webry.info/200706/article_44.html
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DHA:毎日食べて認知症予防に効果 島根大チームが実証
http://mainichi.jp/select/wadai/news/20100203k0000m040111000c.html
毎日新聞 2010年2月2日 22時33分
 青魚に多く含まれるDHA(ドコサヘキサエン酸)やEPA(エイコサペンタエン酸)を毎日食べ続けることで認知症予防に効果があることを、島根大医学部の橋本道男准教授(脂質栄養学)のグループが、高齢者108人に行った試験で実証した。100人規模の高齢者を対象に実際に毎日食物として食べさせるなどする「介入試験」で効果を実証したのは国内初という。7月に米国・ハワイで開催の国際アルツハイマー病会議で発表する。
 島根県立大などと共同で実施。同県在住で65歳以上の健常な高齢者108人(平均年齢73歳)を、二つのグループに分け、一方にDHA850ミリグラム、EPA200ミリグラムを含む魚肉ソーセージ、もう一方にいずれもほとんど含まない魚肉ソーセージを1年間、毎日2本ずつ食べさせた。
 一度見た図形を模写するテストや、あらかじめ決められたルールに沿って指を動かすテストを行ったところ、DHA入りを食べていないグループは成績が低下。DHA入りを食べていたグループは成績が改善し、短期記憶や運動能力などの機能低下が抑制された。
 橋本准教授は「今後は食品を利用した高齢者医療への応用の可能性など、予防医学の観点からも波及効果が期待できる」としている。【細谷拓海】
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Page last updated at 00:02 GMT, Tuesday, 2 February 2010
Fish oil supplements 'beat psychotic mental illness'
http://news.bbc.co.uk/2/hi/health/8490937.stm

画像Fish oil capsules
The capsules are rich in omega-3

Taking a daily fish oil capsule can stave off mental illness in those at highest risk, trial findings suggest.

A three-month course of the supplement appeared to be as effective as drugs, cutting the rate of psychotic illness like schizophrenia by a quarter.

The researchers believe it is the omega-3 in fish oil - already hailed for promoting healthy hearts - that has beneficial effects in the brain.

A "natural" remedy would be welcomed, Archives of General Psychiatry says.

"The finding that treatment with a natural substance may prevent, or at least delay, the onset of psychotic disorder gives hope that there may be alternatives to antipsychotic drugs," the study authors said.


If young people can be treated successfully with fish oils, this is hugely preferable to treating them with antipsychotics
Alison Cobb
Mind

Antipsychotic drugs are potent and can have serious side effects, which puts some people off taking them.

Fish oil supplements, on the other hand, are generally well tolerated and easy to take, say the scientists.

The international team from Austria, Australia and Switzerland tested the treatment in 81 people deemed to be at particularly high risk of developing psychosis.

Natural choice

Their high risk was down to a strong family history of schizophrenia, or similar disorders, or them already showing mild symptoms of these conditions themselves.

For the test, half of the individuals took fish oil supplements (1.2 grams of omega-3 fatty acids) for 12 weeks, while the other half took only a dummy pill. Neither group knew which treatment they were receiving.

Dr Paul Amminger and his team followed the groups for a year to see how many, if any, went on to develop illness.

Two in the fish oil group developed a psychotic disorder compared to 11 in the placebo group.

Based on the results, the investigators estimate that one high-risk adult could be protected from developing psychosis for every four treated over a year.

They believe the omega-3 fatty acids found in the supplements may alter brain signalling in the brain with beneficial effects.

Alison Cobb, of the mental health charity Mind, said: "If young people can be treated successfully with fish oils, this is hugely preferable to treating them with antipsychotics, which come with a range of problems from weight gain to sexual dysfunction, whereas omega-3s are actually beneficial to their general state of health.

"These are promising results and more research is needed to show if omega-3s could be an alternative to antipsychotics in the long term."

----------------------------------------------------
Long-Chain {omega}-3 Fatty Acids for Indicated Prevention of Psychotic Disorders

A Randomized, Placebo-Controlled Trial

G. Paul Amminger, MD; Miriam R. Scha"fer, MD; Konstantinos Papageorgiou, MD; Claudia M. Klier, MD; Sue M. Cotton, PhD; Susan M. Harrigan, MSc; Andrew Mackinnon, PhD; Patrick D. McGorry, MD, PhD; Gregor E. Berger, MD

Arch Gen Psychiatry. 2010;67(2):146-154.

Context The use of antipsychotic medication for the prevention of psychotic disorders is controversial. Long-chain {omega}-3 (omega-3) polyunsaturated fatty acids (PUFAs) may be beneficial in a range of psychiatric conditions, including schizophrenia. Given that {omega}-3 PUFAs are generally beneficial to health and without clinically relevant adverse effects, their preventive use in psychosis merits investigation.

Objective To determine whether {omega}-3 PUFAs reduce the rate of progression to first-episode psychotic disorder in adolescents and young adults aged 13 to 25 years with subthreshold psychosis.

Design Randomized, double-blind, placebo-controlled trial conducted between 2004 and 2007.

Setting Psychosis detection unit of a large public hospital in Vienna, Austria.

Participants Eighty-one individuals at ultra-high risk of psychotic disorder.

Interventions A 12-week intervention period of 1.2-g/d {omega}-3 PUFA or placebo was followed by a 40-week monitoring period; the total study period was 12 months.

Main Outcome Measures The primary outcome measure was transition to psychotic disorder. Secondary outcomes included symptomatic and functional changes. The ratio of {omega}-6 to {omega}-3 fatty acids in erythrocytes was used to index pretreatment vs posttreatment fatty acid composition.

Results Seventy-six of 81 participants (93.8%) completed the intervention. By study's end (12 months), 2 of 41 individuals (4.9%) in the {omega}-3 group and 11 of 40 (27.5%) in the placebo group had transitioned to psychotic disorder (P = .007). The difference between the groups in the cumulative risk of progression to full-threshold psychosis was 22.6% (95% confidence interval, 4.8-40.4). {omega}-3 Polyunsaturated fatty acids also significantly reduced positive symptoms (P = .01), negative symptoms (P = .02), and general symptoms (P = .01) and improved functioning (P = .002) compared with placebo. The incidence of adverse effects did not differ between the treatment groups.

Conclusions Long-chain {omega}-3 PUFAs reduce the risk of progression to psychotic disorder and may offer a safe and efficacious strategy for indicated prevention in young people with subthreshold psychotic states.

Trial Registration clinicaltrials.gov Identifier: NCT00396643


Author Affiliations: Department of Child and Adolescent Psychiatry, Medical University of Vienna, Vienna, Austria (Drs Amminger, Scha"fer, Papageorgiou, and Klier); Orygen Research Centre, Centre for Youth Mental Health, The University of Melbourne, Melbourne, Australia (Drs Amminger, Cotton, Mackinnon, and McGorry and Ms Harrigan); and Department of Research and Education, The Schlo"ssli Clinic, Oetwil am See, Switzerland (Dr Berger).





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