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zoom RSS 自閉症とMMRワクチンの関連論文 ランセットが撤回

<<   作成日時 : 2010/02/04 23:55   >>

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 自閉症とMMRワクチンが関連しているとした研究を発表し信用に傷がついた医学雑誌がその論文を完全に撤回した。The Lancetランセットは研究者による主張が間違いであると認めた。Dr Andrew Wakefieldは先週、医師審議会GMCの研究規則違反で先週制裁措置を受けたことで決定された。論文出版によりワクチン接種率が低下し、麻疹発症が増加した。ランセットはすでに一部撤回する文書を公表していた。
 Dr Wakefieldは、子供がMMRワクチンで障害を受けたと信じた親の代行をしていた法務官(弁護士?)から報酬をもらい、利害対立の中にいた。GMCは研究での不誠実も指摘し、医師登録を抹消するかどうかは今後決定する。
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麻疹流行の危険/英国医療事情
http://kurie.at.webry.info/200709/article_13.html
麻疹流行の深刻化/英国医療事情 はしか ワクチン
http://kurie.at.webry.info/200902/article_14.html
ワクチンと自閉症は関連なしと裁判所が断定/米国医療事情
http://kurie.at.webry.info/200902/article_29.html
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Page last updated at 14:22 GMT, Tuesday, 2 February 2010
Lancet accepts MMR study 'false'
By Nick Triggle
Health reporter, BBC News
http://news.bbc.co.uk/2/hi/health/8493753.stm

画像MMR vaccine
Experts say MMR is completely safe

The medical journal which originally published the discredited research linking autism and MMR has now issued a full retraction of the paper.

The Lancet said it now accepted claims made by the researchers were "false".

It comes after Dr Andrew Wakefield, the lead researcher in the 1998 paper, was ruled last week to have broken research rules by the General Medical Council.

The publication caused vaccination rates to plummet, resulting in a rise in measles.

The Lancet had already issued a partial retraction.


THE WAKEFIELD STORY
MMR is the combined measles, mumps and rubella vaccine which was introduced in the late 1980s
In 1998 the Lancet published a study, led by Dr Andrew Wakefield, which linked the jab with autism and bowel disease
It has since been discredited by medical experts
A newspaper subsequently made allegations about the way the research was carried out
The GMC launched an investigation and ruled he had broken research rules and acted unethically

In 2004, editors argued they had been right to publish it as the journal was there to "raise new ideas".

But they accepted that in hindsight they may not have been, after accusations of a conflict of interest - Dr Wakefield was in the pay of solicitors who were acting for parents who believed their children had been harmed by MMR.

But this move goes further by accepting the research was fundamentally flawed because of a lack of ethical approval and the way the children's illnesses were presented.

The statement added: "We fully retract this paper from the published record."

Last week, the GMC ruled that Dr Wakefield had shown a "callous disregard" for children and acted "dishonestly" while he carried out his research. It will decide later whether to strike him off the medical register.

The regulator only looked at how he acted during the research, not whether the findings were right or wrong - although they have been widely discredited by medical experts across the world in the years since publication.

After the hearing, Dr Wakefield, who now lives and works in the US, said the findings were "unjust and unfounded".

Professor Adam Finn, a leading paediatrician based at the University of Bristol Medical School, said: "This is not before time. Let's hope this will do something to re-establish the good reputation of this excellent vaccine.

"And I hope the country can now draw a line under this particular health scare and move onto new opportunities for vaccination."

----------------------------------------------------
Vaccine-Autism Study Is Retracted
http://www.nytimes.com/aponline/2010/02/02/health/AP-EU-Britain-Medical-Journal.html
By THE ASSOCIATED PRESS
Published: February 2, 2010

Filed at 11:01 a.m. ET

LONDON (AP) -- A major British medical journal on Tuesday retracted a flawed study linking the measles, mumps and rubella vaccine to autism and bowel disease.

The retraction by The Lancet comes a day after a competing medical journal, BMJ, issued an embargoed commentary calling for The Lancet to formally retract the study. The commentary was to have been published on Wednesday.

The BMJ commentary said once the study by British surgeon and medical researcher Andrew Wakefield and his colleagues appeared in 1998 in The Lancet, ''the arguments were considered by many to be proven and the ghastly social drama of the demon vaccine took on a life of its own.''

Since the controversial paper was published, British parents abandoned the vaccine in droves, leading to a resurgence of measles. Subsequent studies have found no proof that the vaccine is connected to autism, though some parents are still wary of the shot.

In Britain, vaccination rates for measles have never recovered and there are outbreaks of the disease every year.

Ten of Wakefield's 13 co-authors renounced the study's conclusions several years ago and The Lancet has previously said it should never have published the research.

''We fully retract this paper from the published record,'' Lancet editors said in a statement Tuesday.

Last week, Britain's General Medical Council ruled that Wakefield had shown a ''callous disregard'' for the children used in his study and acted unethically. Wakefield and the two colleagues who have not renounced the study face being stripped of their right to practice medicine in Britain.

For the study, Wakefield took blood samples from children at his son's birthday party, paying them 5 pounds each ($8) for their contributions and later joking about the incident.


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