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zoom RSS 片頭痛に対するアスピリンの効果

<<   作成日時 : 2010/04/17 23:59   >>

なるほど(納得、参考になった、ヘー) ブログ気持玉 1 / トラックバック 0 / コメント 0

 アスピリン服用後2時間で50%以上の人の片頭痛の痛みが軽減する。13の研究データからコクランの体系的レビューで判明した。アスピリン多量服用で、片頭痛の症状である吐き気・嘔吐・光や音過敏を抑制できる。
 しかし、副作用の可能性や依存症の可能性もあるので注意が必要である。
 4,222人のデータのレビューによれば、重度ないし中等度の片頭痛発作の1/4が完全に軽快した。900-1000mgの1回投与で2時間以内で効果がでる。頭痛完全消失はプラセーボでは1/10だった。2人に1人は頭痛は軽度以下となった。プラセーボでは3人に1人だった。鎮吐剤を併用すると吐き気や嘔吐に対して効果が高かった。
 誰にでも効くわけではなく、遺伝的に反応が異なることによる。
 アセトアミノフェンとイブプロフェンの効果について現在レビューが行われているという。
------------------------
アスピリンで乳ガン再発予防
http://kurie.at.webry.info/201002/article_16.html
アスピリンで大腸癌の死亡率が低下
http://kurie.at.webry.info/200908/article_21.html
アスピリン服用で非噴門部胃ガンのリスクが減少する
http://kurie.at.webry.info/200902/article_28.html
長期アスピリン服用で結腸直腸ガンのリスクが低下する
http://kurie.at.webry.info/200902/article_27.html
アスピリンに乳がん予防効果
http://kurie.at.webry.info/200805/article_33.html
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Page last updated at 00:49 GMT, Wednesday, 14 April 2010 01:49 UK
Aspirin can reduce migraine symptom pain, review says
http://news.bbc.co.uk/2/hi/health/8617254.stm

画像Some aspirin pills and a glass of water
Many migraine sufferers choose to use over the counter medicines

Taking aspirin can reduce the pain of a migraine headache within two hours for over 50% of people, research says.

The results come from a Cochrane Systematic Review using data from 13 studies.
Researchers found that a high dose of aspirin also reduces nausea, vomiting and sensitivity to light or sound - other symptoms of a migraine.
But experts stress aspirin can cause side effects and some people will still need to rely on migraine medication.

Pain relief
In the review, which looked at the data from 4,222 participants, researchers found that severe or moderate migraine headache pain was completely relieved in one in four people.
This happens within two hours, by taking a single dose of 900-1,000mg aspirin alone (a standard tablet is 300mg).

In comparison, one in 10 had complete pain relief taking placebo.
And for one in two people, the headache pain was reduced to no worse than mild pain, compared to one in three taking placebo.
Researchers also found that a combination of aspirin plus an anti-emetic, which stops people feeling sick, was particularly good at reducing the migraine symptoms of nausea and vomiting. However, it did not produce any greater pain relief.

Migraine sufferers should consult their GP to get a firm diagnosis of their headache even if over the counter medication is effective
Wendy Thomas, The Migraine Trust

Co-author of the study, Sheena Derry, who works in pain research at the John Radcliffe Hospital in Oxford, said the use of aspirin would not be an effective therapy for everyone with acute migraine attacks.
"This is largely down to genetic differences," she said. "Different people respond to different drugs in different ways, and at different times."
Researchers say that further studies are needed to establish the effectiveness of aspirin compared with other drugs.

Firm diagnosis
"We are currently doing reviews of how paracetamol and ibuprofen impact on migraines," Ms Derry added.
Taking aspirin resulted in only a small increase in mostly mild side effects in the participants in the studies.
However the authors said: "While short-term use of aspirin probably does not pose a large problem the potential for gastrointestinal harm with long-term use is well documented."
Wendy Thomas, chief executive of The Migraine Trust, said the first stop for migraine sufferers should always be their GP, "to get a firm diagnosis of their headache even if they find over the counter medication to be effective".

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Aspirin with or without an antiemetic for acute migraine headaches in adults
Kirthi V, Derry S, Moore RA, McQuay HJ

http://www2.cochrane.org/reviews/en/ab008041.html

Summary
Aspirin with or without an antiemetic for acute migraine headaches in adults

A single oral dose of 1000 mg of aspirin is effective in relieving migraine headache pain and associated symptoms (nausea, vomiting, photophobia, phonophobia). Pain will be reduced from moderate or severe to no pain by 2 hours in approximately 1 in 4 people (24%) taking aspirin, compared with about 1 in 10 (11%) taking placebo. Pain will be reduced from moderate or severe to no worse than mild pain by 2 hours in roughly 1 in 2 people (52%) taking aspirin compared with approximately 1 in 3 (32%) taking placebo. Of those who experience effective headache relief at 2 hours, more have that relief sustained over 24 hours with aspirin than with placebo. Addition of 10 mg of the antiemetic metoclopramide substantially increases relief of nausea and vomiting compared with aspirin alone, but makes little difference to pain.

This is a Cochrane review abstract and plain language summary, prepared and maintained by The Cochrane Collaboration, currently published in The Cochrane Database of Systematic Reviews 2010 Issue 4, Copyright © 2010 The Cochrane Collaboration. Published by John Wiley and Sons, Ltd.. The full text of the review is available in The Cochrane Library (ISSN 1464-780X).
This record should be cited as: Kirthi V, Derry S, Moore RA, McQuay HJ. Aspirin with or without an antiemetic for acute migraine headaches in adults. Cochrane Database of Systematic Reviews 2010, Issue 4. Art. No.: CD008041. DOI: 10.1002/14651858.CD008041.pub2

Editorial Group: Pain, Palliative and Supportive Care Group

This version first published online: April 14. 2010
Last assessed as up-to-date: April 15. 2010


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