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zoom RSS 超音波による可逆性の避妊治療

<<   作成日時 : 2010/05/20 23:55   >>

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画像 超音波が可逆性の避妊治療に使用できるか確認試験を開始した。ノース・カロライナ大の初期の研究で睾丸への超音波照射により6ヶ月間精子の生産を止めることができた。ゲイツ財団からの100,000ドルの補助金により、より多くの臨床試験をおこなう予定である。安価で長期の可逆性避妊治療を目標としている。
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Page last updated at 09:57 GMT, Tuesday, 11 May 2010 10:57 UK
Scientists to test ultrasound as a male contraceptive
http://news.bbc.co.uk/2/hi/health/8674380.stm

Scientists are beginning tests to see if ultrasound can be used as a reversible contraceptive for men.

Based on early work, University of North Carolina experts believe a blast of ultrasound to the testes can safely stop sperm production for six months.

With a grant of $100,000 from the Bill & Melinda Gates Foundation they will push ahead with more clinical trials.

The researchers ultimately hope it could offer a new birth control option to couples throughout the world.

Lead researcher Dr James Tsuruta said: "We think this could provide men with up to six months of reliable, low-cost, non-hormonal contraception from a single round of treatment.

"Our long-term goal is to use ultrasound from therapeutic instruments that are commonly found in sports medicine or physical therapy clinics as an inexpensive, long-term, reversible male contraceptive suitable for use in developing to first world countries."

Once the testis has stopped producing sperm and all "sperm reserves" have been depleted, explain the researchers, the man will be temporarily infertile.

Their Grand Challenges Exploration Grant project aims at fine-tuning this technique for maximum effect and safety.


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UNC researchers receive $100,000 Grand Challenges Exploration Grant to develop male contraceptive
http://www.med.unc.edu/www/news/unc-researchers-receive-100-000-grand-challenges-exploration-grant-to-develop-male-contraceptive
Monday, May 10, 2010 ― The grant will support an innovative global health research project conducted by James Tsuruta, PhD, and Paul Dayton, PhD, titled “Ultrasound as a long-term, reversible contraceptive.”
UNC researchers receive $100,000 Grand Challenges Exploration Grant to develop male contraceptive
The testis is composed of many tubes called “seminiferous tubules.” The seminiferous tubule on the left is from a testis that was not treated with ultrasound while the tubule on the right is from a testis that was treated with ultrasound. Note that the tubule from the control testis has many darkly stained germ cell nuclei. Most germ cell nuclei are round; the long, thin nuclei closest to the center of the tubule belong to germ cells called spermatids and they will soon be released as testicular sperm. In contrast, the ultrasound-treated tubule is completely lacking testicular sperm and has lost almost all immature germ cells, decreasing its overall diameter while greatly increasing the amount of “empty” space in the center of the tubule.
CHAPEL HILL ― The University of North Carolina at Chapel Hill has received a $100,000 Grand Challenges Explorations grant from the Bill & Melinda Gates Foundation. The grant will support an innovative global health research project conducted by James Tsuruta, PhD, and Paul Dayton, PhD, titled “Ultrasound as a long-term, reversible contraceptive.”

Tsuruta is an assistant professor in the Laboratories for Reproductive Biology in UNC’s Department of Pediatrics. Dayton is associate professor and director of graduate studies in the Department of Biomedical Engineering, which is jointly housed at UNC and N.C. State University.
tsuruta.jpg
James Tsuruta, PhD

Tsuruta and Dayton’s project is one of 78 grants announced by the Gates Foundation in the fourth funding round of Grand Challenges Explorations, an initiative to help scientists around the world explore bold and largely unproven ways to improve health in developing countries. The grants were provided to scientists in 18 countries on six continents.

To receive funding, Tsuruta and Dayton showed in a two-page application how their idea falls outside current scientific paradigms and might lead to significant advances in global health. The initiative is highly competitive, receiving almost 2,700 proposals in this round.

“Our long-term goal is to use ultrasound from therapeutic instruments that are commonly found in sports medicine or physical therapy clinics as an inexpensive, long-term, reversible male contraceptive suitable for use in developing to first world countries,” said Tsuruta.

dayton.jpg
Paul Dayton, PhD

"We think this could provide men with up to six months of reliable, low-cost, non-hormonal contraception from a single round of treatment,” Tsuruta said. Tsuruta notes that the initial idea to re-examine the effects of ultrasound on sperm production came from another private foundation. “The financial support of the Parsemus Foundation was instrumental in forming a team to study ultrasound’s effect on the testis. Our pilot studies would not have been possible without the support of Elaine Lissner (Parsemus), David Sokal (Family Health International), Michael Streicker (Integrated Laboratory Systems) and Michael O'Rand (UNC-CH).

Tsuruta and Dayton have successfully depleted testicular sperm using therapeutic ultrasound instruments. Once the testis has stopped producing sperm and all “sperm reserves” have been depleted, it is impossible to be fertile. Their Grand Challenges Exploration Grant project is aimed at fine-tuning this technique for maximum effect and safety.

“The winners of these grants show the bold thinking we need to tackle some of the world’s greatest health challenges,” said Dr. Tachi Yamada, president of the Gates Foundation’s Global Health Program. “I’m excited about their ideas and look forward to seeing some of these exploratory projects turn into life-saving breakthroughs.”

Media contact: Tom Hughes, (919) 966-6047, tahughes@unch.unc.edu
About Grand Challenges Explorations

Grand Challenges Explorations is a five-year, $100 million initiative of the Gates Foundation to promote innovation in global health. The program uses an agile, streamlined grant process -- applications are limited to two pages, and preliminary data are not required. Proposals are reviewed and selected by a committee of foundation staff and external experts, and grant decisions are made within approximately three months of the close of the funding round.

Applications for the current round of Grand Challenges Explorations are being accepted through May 19, 2010. Grant application instructions, including the list of topics for which proposals are currently being accepted, are available at http://www.grandchallenges.org/explorations.

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