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zoom RSS 自閉症の食事療法は効果なし/米国 グルテン・カゼイン

<<   作成日時 : 2010/05/21 23:56   >>

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画像 自閉症の子どもに対して良く知られたグルテン・カゼインなしの食餌は症状改善せずとの新たな研究発表。
 グルテンはコムギの、カゼインは乳製品のたんぱく質であり、それを除去したGFCFと呼ばれる食事では、注意力、睡眠などへの効果がなかったが、胃腸症状をもつ子どもに対しては利点があるという。
 ランダム化二重盲検による検証による結果がフィラデルファアで開催の国際会議で発表される。
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A Gluten-Free, Casein-Free Diet No Remedy for Autism
Popular Diet Does Not Ease Behavioral, Gastrointestinal Symptoms, Study Finds
http://abcnews.go.com/Health/Autism/gluten-free-casein-free-diet-remedy-autism-study/story?id=10690766
By DAN CHILDS, LARA SALAHI and PAMELA MAZZEO, M.D.
ABC News Medical Unit
May 19, 2010

A popular diet intended to curb the effects of autism received yet another blow today in the form of a new study that found that autistic children who adhered to a gluten-free, casein-free diet showed no improvement in their symptoms.
Despite a recent report, the actress and activist says autism diets are helpful.

Gluten is a protein found in wheat, and casein is a protein found in dairy products.

Dr. Susan Hyman, lead author of the study, said she knows that some families would be surprised by the team's findings, especially given the reports of dramatic clinical improvement observed by many families using the diet.

"It would have been wonderful for children with autism and their families if we found that the GFCF [gluten-free, casein-free] diet could really help, but this small study didn't show significant benefits," Hyman, an associate professor of pediatrics at Golisano Children's Hospital at the University of Rochester Medical Center, said in a statement. But she did say it was possible that children with significant gastrointestinal disease would reap some benefits from the diet.

Still, Tracey McCollum, the mother of one of the children in the study, said the results were personally disheartening.

"We were hoping to show that the diet made a difference, give a lot of parents some hopes that, 'Here's a magic bullet; here is something that I can do proactively that will help my child," she said. "As a parent you want to do everything you can to help your child do the best he can in life."

The study will be presented May 22 at the International Meeting for Autism Research in Philadelphia.

The researchers undertook a randomized, double-blinded (meaning neither the participants nor the researchers knew which treatment anyone received), placebo-controlled study.

Fourteen children who were put on the diet for at least four weeks were then given snacks containing gluten, casein, both or neither. The researchers evaluated the children for changes in attention, sleep, stool patterns and characteristic autistic behavior. The study did not show significant changes in any of these symptoms for any of the groups.

Dr. Leonard Rappaport, chief of the Division of Developmental Medicine at Children's Hospital in Boston, called the findings "disappointing."

"Even though I did not believe it really made a difference, I was hoping I was wrong," Rappaport said.


Dr. Ari Brown, a pediatrician and author of the books "Expecting 411," "Baby 411" and "Toddler 411," said that though she believes the study is "far from definitive," the results were not unanticipated.

"I have had many families who have tried GFCF diets and have not found a real difference in their children's behaviors," she said. "I do have a few who claim it does help, but those children also are involved in some behavioral therapy, so it is hard to tease out which treatment has been beneficial."

But David Amaral, president of the International Society for Autism Research and professor at the University of California at Davis, said that the findings may not necessarily be cause for dismay among parents of autistic children.

"Actually, I don't think that many parents will be disappointed," Amaral said. "On the contrary, it is very difficult to maintain children on the [GFCF] diet. Some parents who may have failed in maintaining the diet may feel relieved to hear that it might not be a benefit to their child even if they had persisted."

Gluten-Free Diets, Alternative Therapies, Commonly Tried for Autism

Many parents of autistic children look to alternative therapies, including special diets. According to Dr. Daniel Coury, medical director of the Autism Treatment Network, about 20 percent of parents within the the network use complementary methods to treat their autistic children, and more than half of them rely to some extent on diets.

In particular, parents of autistic children often report improvements with the popular but scientifically unproven gluten-free, casein-free diet.

This diet has been promoted by celebrities such as Jenny McCarthy, whose best-selling book, "Louder Than Words," detailed her use of diets as one way of treating her autistic son. Many autism communities have also touted the purported benefits of specialized diets for their children.

While many parents of children with autism report gastrointestinal pain in their children, the question remains whether the association between autism and bowel disease exists.

Some Parents Report No Success With Autism Diet

Not all parents have had success with the diets. Diane Marshall, 42, of Montclair, N.J., put her son David, 13, on a gluten-free, casein-free diet for a year when he was 4 years old. Marshall said she'd read success stories from some mothers who tried the diet for their autistic children. At the time, David had severe eczema and runny bowel movements, she said.

"We definitely thought the diet would help the autism," said Marshall.

Although the gastrointestinal issues subsided, Marshall said she did not attribute the end of her son's stomach problems to the diet. And she said the diet did not help her son overcome autism.

"There are a lot of things out there that are based on evidence, like teaching methods, that will help our kids a lot, but not diets," said Marshall.

"There has not been any research to substantiate the GFCF diet for children with autism who do not have celiac disease or wheat/milk allergies," said Dr. Stefani Hines, a development-behavioral pediatrician at William Beaumont children's hospital in Royal Oak, Mich.

But this does not mean that parents are necessarily empty-handed when it comes to scientific approaches to improving autism symptoms, Hines said.

"So far the research that has been the most promising has been aimed at applied behavioral analysis," she said. "We still have much to learn regarding best treatment practices for children with autism."

Study author Hyman said more research needs to be done in this area with similar rigor but with larger numbers, so that subtle effects can be detected. It's important, she said, for families to get the best information they can in deciding which interventions to pursue.

She also said families who elect to make dietary changes need to pay careful attention to general nutrition. "When you eliminate dairy as an entire category, you need to pay attention to vitamin D, calcium and protein," she said.

Guiding Parents Through Autism Options Important, Doctors Say

Rappaport agreed. "I hope that parents will go into these diets with their eyes open -- using a nutritionist to guide them -- and even if there seems to be anecdotal improvement, that they try the child off this restrictive diet after a while to see if it actually makes a difference."

In the meantime, Hines said doctors should not be surprised if parents continue to use the diet to try to improve autism symptoms in their children, despite the weight of the research.

"Autism is a chronic, lifelong condition with no known cure," Hines said. "Parents will continue to try everything out there to make sure they aren't missing anything that could possibly help their child.

"Our job as care providers is to help them along in this process and to try to wade through all the data with them to make the best-informed decisions. "

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http://imfar.confex.com/imfar/2010/webprogram/Paper6183.html

The Gluten Free and Casein Free (GFCF) Diet: A Double Blind, Placebo Controlled Challenge Study
Saturday, May 22, 2010: 2:45 PM
Grand Ballroom AB Level 5 (Philadelphia Marriott Downtown)
1:15 PM
S. Hyman , Strong Center for Developmental Disabilities, Pediatrics, University of Rochester, Rochester, NY
P. A. Stewart , General Clinical Research Center, University of Rochester, Rochester, NY
T. Smith , Strong Center for Developmental Disabilities, University of Rochester, Rochester, NY
J. Foley , Pediatrics, University of Rochester, Rochester, NY
U. Cain , General Clinical Research Center, University of Rochester, Rochester, NY
R. Peck , General Clinical Research Center, University of Rochester, Rochester, NY
D. D. Morris , Pediatrics, University of Rochester, Rochester, NY
H. Wang , Biostatistics and Computational Biology, University of Rochester, Rochester, NY
Background: Approximately 1/3 of children with ASD receive dietary interventions. While families report dramatic clinical effects, two prior trials do not confirm these positive outcomes. Neither examined nutritional sufficiency or controlled for other interventions. This study was undertaken to examine the behavioral and physiologic effects of the GFCF diet and assess its nutritional adequacy.
Objectives: To evaluate the nutritional adequacy, physiological effects, and efficacy of the GFCF diet on symptoms of ASD using randomized double blind placebo controlled challenges in preschool children with ASD. Methods: ADI-R/ADOS positive children ages 30-54 months receiving at least 10 hours/week of early intensive behavioral intervention (EIBI) were recruited. They were screened for milk/wheat allergies, celiac disease, and anemia/iron status by RAST, TTG and CBC/ferritin respectively. After a strict GFCF diet for at least 4 weeks, they received weekly, grouped, randomized double blind challenges containing either 20 g wheat flour, 20 g evaporated milk, both, or neither on three separate occasions over 12 weeks . The challenges appeared identical and were similar in taste and texture. Laboratory monitoring and BMI recording occurred at baseline, 6,18,and 30 weeks. Behavioral data was collected at these times plus the day before then 2 and 24 hours after each challenge, Measures included: Bristol Stool Scale, Sleep Diaries, Actigraphy, Conners Abbreviated Rating Scale, and Target Symptoms Scale. Ritvo Freeman Real Life Rating Scales (RFRLRS) were recorded at 2 and 24 hours post challenge. Challenges occurred only if measures were at baseline levels. Data were analyzed by group and for individual children comparing baseline with 4 weeks on diet and then pre/post challenges.
Results: Twenty one children were recruited. Two were excluded for positive TTG, one for anemia. Four additional children were unable to establish the diet or left EIBI. Group data on the 14 successful participants (43.5 months, range 35-54 ; 12 males) demonstrated no statistical change in frequency or quality of stools, sleep, actigraphy for activity, or parent/teacher/observer scores of attention/activity for baseline/ diet or in pre/post challenge ratings. The group RFRLRS data 2 hours post challenge were higher after placebo than after challenges of casein (p=.013), gluten (p=0.024) or gluten + casein (p= 0.021). These differences were not present 24 hours post challenge. Single case analysis will be presented. All children were maintained within acceptable ranges for micro/macronutrients with intense weekly dietary monitoring.
Conclusions: This is the first study to examine the behavioral effects of a nutritionally monitored GFCF diet on attention, sleep, stool pattern, and core symptoms of ASD. While no favorable effects of the GFCF diet on attention, sleep and stool patterns were identified in group analyses, such effects may occur for individuals or for subgroups of children (e.g. with significant GI disease), providing the basis for positive anecdotal reports. Future studies need to address the potential effects of nutrition on behavior in children with ASD and be powered to evaluate subtle changes in core symptoms.
Funded by STAART NIMH PO1HD35466 and National Center for Research Resources (NCRR) NIH UL1RR024160; Autism Treatment Network/Autism Speaks -- AIRP Network(HRSA)

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