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zoom RSS 遺伝子変異と殺虫剤暴露の組み合わせでパーキンソン病の発病リスクが増大

<<   作成日時 : 2010/06/15 23:48   >>

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 遺伝子変異と殺虫剤の暴露の組み合わせでパーキンソン病の発病リスクが増大するというフランスからの報告。
 全体的にはABCB1遺伝子の突然変異はパーキンソン病リスクと関連しなかったが、有機塩素系殺虫剤暴露とパーキンソン病の関連がBCB1遺伝子の2つの変異により3.5倍高くなるとわかった。
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Genetics, Insecticides Might Contribute to Parkinson's
French study found combination raised risk of movement disorder in men
-- Robert Preidt
http://health.msn.com/health-topics/articlepage.aspx?cp-documentid=100260259

French study found combination raised risk of movement disorder in men.

MONDAY, June 14 (HealthDay News) -- A combination of genetic mutations and exposure to insecticides may increase a man's risk of Parkinson's disease, new research shows.

The study included 207 Parkinson's disease patients and a control group of 482 healthy people. The French team of researchers analyzed the participants for mutations in a gene called ABCB1 and assessed their lifetime exposure to pesticides.

Overall, mutations in the ABCB1 gene weren't associated with Parkinson's disease risk. However, the researchers found that the association between organochlorine insecticide exposure and Parkinson's disease was 3.5 times stronger in men with two mutated copies of the ABCB1 gene than among those with no ABCB1 mutations.

"Based on a biological hypothesis, we show that organochlorine insecticides may interact with ABCB1 in determining the risk of Parkinson's disease," Fabien Dutheil, of Universite Paris Descartes, Assistance-Publique Hopitaux de Paris, and colleagues concluded. "These findings support the hypothesis of gene x pesticide interactions in Parkinson's disease."

The study is published in the June issue of the Archives of Neurology.

More information

The American Academy of Family Physicians has more about Parkinson's disease.
SOURCE: JAMA/Archives journals, news release, June 14, 2010

Copyright @2010 HealthDay. All Rights Reserved.

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画像Interaction Between ABCB1 and Professional Exposure to Organochlorine Insecticides in Parkinson Disease

Fabien Dutheil, PhD; Philippe Beaune, Pharm, PhD; Christophe Tzourio, MD, PhD; Marie-Anne Loriot, Pharm, PhD; Alexis Elbaz, MD, PhD

Arch Neurol. 2010;67(6):739-745.

Objective To study the association between Parkinson disease (PD) and 2 polymorphisms in ABCB1 among subjects enrolled in the French health system for agricultural workers (Mutualité Sociale Agricole), as well as the interaction between ABCB1 and organochlorine insecticides.

Design Case-control study.

Setting Mutualité Sociale Agricole.

Participants Patients with PD were examined by a neurologist and were matched to a maximum of 3 controls. Participants were classified as never users, users for gardening, and professional users of pesticides. Detailed information on pesticides lifelong use was obtained for professional users by occupational health physicians.

Main Outcome Measures DNA was obtained and 2 ABCB1 polymorphisms (exon 21: G2677[A,T]; exon 26: C3435T) associated with altered P-glycoprotein function were genotyped.

Results Among 207 cases and 482 matched controls, ABCB1 polymorphisms were not associated with PD (C3435T, P = .43; G2677[A,T], P = .97). Among 101 male cases and 234 matched controls, the odds ratio for organochlorines was 3.5 (95% confidence interval, 0.9-14.5) times higher among homozygous carriers of variant G2677(A,T) alleles than noncarriers. Among cases only, we found an association between carrying 2 variant G2677(A,T) alleles and organochlorines (odds ratio, 5.4, 95% confidence interval, 1.1-27.5) as well as with the number of cumulative lifetime number of hours of exposure (P = .005; analyses restricted to subjects exposed to organochlorines, P = .03).

Conclusions Our findings suggest that the ABCB1 gene and exposure to organochlorine insecticides interact to increase PD risk: in subjects professionally exposed to organochlorines, polymorphisms associated with a decreased ability of ABCB1 to clear xenobiotics from the brain increased the risk of PD. These findings support the hypothesis of gene x pesticides interactions in PD.

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