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<<   作成日時 : 2010/09/21 20:26   >>

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 呼吸器感染をおこすウイルスが肥満と関係しているというが、議論は多い。
 最新の研究では、特定のウイルスの抗体を持つ子どもはそうでない子どもに比べて35ポンド(15.8kg)も体重が重い。
 以前の研究では、同じタイプのウイルスを感染させたニワトリとマウスで体重増加が見られた。
 AD36ウイルス(アデノウイルス36)と成人の肥満が関連ありという研究も以前出された。 8-18才の124人の子どもについてのカリフォルニア大の研究では、19人にAD36抗体が見られたが、そのうち15人は肥満であったという。
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肥満はウイルス感染による可能性
http://kurie.at.webry.info/200708/article_35.html
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20 September 2010 Last updated at 03:56 GMT
Virus 'link' to childhood obesity
http://www.bbc.co.uk/news/health-11346682

画像A virus which causes respiratory infections has been linked to childhood obesity, in a study that is likely to reignite a controversial debate.

Previous animal research has implicated common viruses in weight gain, but the evidence has been disputed.

The latest study, in Pediatrics, found that obese children with antibodies specific to a certain virus weighed 35lbs (15.8kg) more than those without.

Nothing has yet been proven on this theory, say UK experts.

Previous research has shown that chicken or mice injected with similar types of viruses showed a statistically significant weight gain.

A link between the AD36 virus (adenovirus 36) and obesity in human adults has also been written about previously.

But how AD36 infects people and why it affects people differently is still not known.

Antibodies found

In the University of California study of 124 children aged eight to 18, half of the children were considered obese based on their Body Mass Index.

The researchers found the AD36 antibodies in 19 of the children, 15 of whom were in the obese group.

Within the group of obese children studied, those with evidence of AD36 infection weighed an average of 35lbs more than obese children who were AD36-negative, says the study.

Jeffrey Schwimmer, lead researcher and professor of clinical paediatrics at the University of California school of medicine, said he hoped his research would change attitudes to obese people.

"Many people believe that obesity is one's own fault or the fault of one's parents or family. This work helps point out that body weight is more complicated than it's made out to be.

"And it is time that we move away from assigning blame in favour of developing a level of understanding that will better support efforts at both prevention and treatment.

"These data add credence to the concept that an infection can be a cause or contributor to obesity," he said.

Julian Hamilton-Shield, professor in diabetes and metabolic endocrinology at the School of Clinical Sciences, University of Bristol, says the jury is still out on this idea.

"It's an interesting if small and non-definitive study. This does not show causation, just an association.

"For instance, it may be that obese people are at more risk of catching AD36.

"However, it does add a little evidence to suggestions that AD36 may be implicated in some way with childhood obesity," he said.

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Published online September 20, 2010
PEDIATRICS (doi:10.1542/peds.2009-3362)
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Adenovirus 36 and Obesity in Children and Adolescents
Charles Gabbert, MDa,b, Michael Donohue, PhDc, John Arnold, MDd, Jeffrey B. Schwimmer, MDa,e

Departments of aPediatrics,
bMedicine, and
cFamily and Preventive Medicine, School of Medicine, University of California, San Diego, La Jolla, California;
dDepartment of Pediatrics, Naval Medical Center, San Diego, California; and
eDepartment of Gastroenterology, Rady Children's Hospital San Diego, San Diego, California

Objective The primary aim of this study was to assess the relationship between adenovirus 36 (AD36)-specific antibodies and obesity in children.

Methods A cross-sectional study of children 8 to 18 years of age was performed. Children were classified according to BMI percentile as nonobese (<95th percentile) or obese (?95th percentile). The presence of AD36-specific neutralizing antibodies was assessed by using the serum neutralization assay.

Results A total of 124 children (median age: 13.6 years) were studied. Of those children, 46% were nonobese and 54% were obese. AD36 positivity was present in 19 children (15%). The majority of children found to be AD36-positive were obese (15 [78%] of 19 children). AD36 positivity was significantly (P < .05) more frequent in obese children (15 [22%] of 67 children) than nonobese children (4 [7%] of 57 children). Among the subset of children who were obese, those who were AD36-positive had significantly larger anthropometric measures, including weight, BMI, waist circumference, and waist/height ratio.

Conclusion These data support an association of obesity and higher body weight with the presence of neutralizing antibodies to AD36 in children. If a cause-and-effect relationship is established, it would have considerable implications for the prevention and treatment of childhood obesity.


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