医師の一分

アクセスカウンタ

zoom RSS 乳がん検診マンモグラフィーの効用はわずか?

<<   作成日時 : 2010/09/25 23:57   >>

なるほど(納得、参考になった、ヘー) ブログ気持玉 1 / トラックバック 0 / コメント 0

 新たな研究によれば、乳がんの死亡率減少はマンモグラフィーというよりも意識の向上と治療の進歩によるという。
 40代・50代以降のほとんどの女性が国の推奨により毎年マンモグラフィーを受けているが、スクリーニング検査を受けるかどうかはあまり重要ではないかもしれない。
 乳がんの最新医療においてマンモグラフィー乳房X線撮影の利点を評価した最初の研究である。専門家は検査の持つ意味に疑いを持ってはいるが、議論に決着が付いたというわけではなく、ホルモン療法と標的薬による治療成績の向上により、マンモグラフィーによる利点がほとんどなくなってしまったようである。
 数十年前のマンモグラフィーについての研究では、乳がん死亡率を15-25%有意に減少させたとされていたが、その時点では治療効果がずっと低かった。
 新たな研究では、現在の治療と結びついたマンモグラフィーは死亡率を10%減少させたけれども、研究データからは、マンモグラフィーだけの効果が2%または0と同じくらい低いかもしれないとわかった。10%の低下は、1,000人の50歳の女性が10年間スクリーニングされた場合に、995.6人ではなく996人の女性が癌で死なないであろうということを意味するというほど小さな値である。ノルウェーでの1996年の前後(1986-2005)の乳がんと診断された40,075人のデータを元にした研究である。その間に、4,791人が死亡した。ノルウェーは1996年から50〜69才の女性にマンモグラフィーを提供し始めた。
 マンモグラフィーで見つかり特別なチームで治療を受けた場合に、そうでない場合より死亡率は10%低かった。しかし、マンモグラフィーを受けず、新しい治療チームで治療を受けた場合は8%低かった。従って、マンモグラフィーは乳がんの死亡率をたった2%減少させたに過ぎず、誤差範囲であるという。
 50歳以上の2,500人を10年間スクリーニングした場合、1,000人ががんを疑われてフォローアップの検査が行われ、500人が生検を受け、5-15人が放置しても発育が遅いと思われるがんに治療が行われる。
 ノルウェーでは独立した2人の放射線科医によりマンモグラフィーの読影が行われ、乳がん死亡率を1/3減少させると期待されたのだが、結果は驚くべきものだった。

-----------------------
英国でマンモグラフィの有用性に議論/英国医療事情
http://kurie.at.webry.info/200904/article_1.html
デジタル・マンモグラフィーで再検査が増加
http://kurie.at.webry.info/200804/article_17.html
消えた乳がん/乳癌の自然消滅
http://kurie.at.webry.info/200811/article_51.html
----------------------------------------------------
Mammograms’ Value in Cancer Fight at Issue
Damian Dovarganes/Associated Press
By GINA KOLATA
Published: September 22, 2010
http://www.nytimes.com/2010/09/23/health/research/23mammogram.html

画像A radiologist reviewing mammogram images at the Elizabeth Center for Cancer Detection in Los Angeles. Most health officials recommend the screenings, but experts disagree over their value.

A new study suggests that increased awareness and improved treatments rather than mammograms are the main force in reducing the breast cancer death rate.

Starting in their 40s or 50s, most women in this country faithfully get a mammogram every year, as recommended by health officials. But the study suggests that the decision about whether to have the screening test may now be a close call.

The study, medical experts say, is the first to assess the benefit of mammography in the context of the modern era of breast cancer treatment. While it is unlikely to settle the debate over mammograms ― and experts continue to disagree about the value of the test ― it indicates that improved treatments with hormonal therapy and other targeted drugs may have, in a way, washed out most of mammography’s benefits by making it less important to find cancers when they are too small to feel.

Previous studies of mammograms, done decades ago, found they reduced the breast cancer death rate by 15 to 25 percent, a meaningful amount. But that was when treatment was much less effective.

In the new study, mammograms, combined with modern treatment, reduced the death rate by 10 percent, but the study data indicated that the effect of mammograms alone could be as low as 2 percent or even zero. A 10 percent reduction would mean that if 1,000 50-year-old women were screened over a decade, 996 women rather than 995.6 would not die from the cancer ― an effect so tiny it may have occurred by chance.

The study, published Thursday in The New England Journal of Medicine, looked at what happened in Norway before and after 1996, when the country began rolling out mammograms for women ages 50 to 69 along with special breast cancer teams to treat all women with breast cancer.

The study is not perfect. The ideal study would randomly assign women to have mammograms or not. But, cancer experts said, no one would do such a study today when mammograms are generally agreed to prevent breast cancer deaths. In the study, which is continuing, women were followed for a maximum of 8.9 years. It is possible that benefits may emerge later.

Nonetheless, the new study is “very credible,” said Dr. Barnett Kramer, associate director for disease prevention at the National Institutes of Health.

“This is the first time researchers used real populations to compare the effects of treatment and mammography in the modern era of treatment,” Dr. Kramer said. “It shows the relative impacts of screening versus therapy in an era in which therapy has been improving.”

Dr. Otis Brawley of the American Cancer Society said in a statement that the investigators used “careful methodology.” The society, Dr. Brawley said, “believes that the total body of the science supports the fact that regular mammography is an important part of a woman’s preventive health care.”

Dr. Carol Lee, a radiologist at Memorial Sloan-Kettering Cancer Center and chairwoman of the breast imaging commission of the American College of Radiology, said the new study affirmed that mammography saves lives.

“Mortality from breast cancer is decreasing, and I have to believe that screening mammography has played a part,” Dr. Lee said.

In their study, the investigators analyzed data from all 40,075 Norwegian women who had received a diagnosis of breast cancer from 1986 to 2005, a time when treatment was changing markedly.

In that period, 4,791 women died. And, starting in 1996, Norway began offering mammograms to women ages 50 to 69 and assigning multidisciplinary treatment teams to all women with breast cancer, similar to the teams at many major medical centers in the United States. The question was, Did the program of mammograms and optimal new treatment with coordinated teams of surgeons, pathologists, oncologists, radiologists and nurses lower the breast cancer death rate?

The investigators found that women 50 to 69 who had mammograms and were treated by the special teams had a 10 percent lower breast cancer death rate than similar women who had had neither.

They also found, though, that the death rate fell by 8 percent in women over 70 who had the new treatment teams but had not been invited to have mammograms. And Dr. Kramer said he knew of no evidence that breast cancer was more easily treated in women over 70 than in women ages 50 to 69.

That means, Dr. H. Gilbert Welch of Dartmouth wrote in an additional analysis in an accompanying editorial, that mammography could have reduced the breast cancer death rate by as little as 2 percent, an amount so small that it is not really different from zero.

Two percent is an estimate, Dr. Welch said. But, he said, whatever the effect of mammograms is, “all the signals here are that it is much smaller than we believed.”

Dr. Laura Esserman, a professor of surgery and radiology at the University of California in San Francisco, said it tells her that “if you get the same treatment and the outcome is the same if you find it earlier or later, then you don’t make a difference when you find it early.”

And screening has a cost, Dr. Welch said. Screening 2,500 50-year-olds for a decade would identify 1,000 women with at least one suspicious mammogram resulting in follow-up tests. Five hundred would have biopsies. And 5 to 15 of those women would be treated for cancers that, if left alone, would have grown so slowly they would never have been noticed.

When the study was planned, the scientists expected that screening would be even more effective than it was in studies from decades ago. After all, mammography had improved and, in Norway, each mammogram was independently read by two radiologists, which should make it less likely that cancers would be missed. The researchers expected mammograms to reduce the breast cancer death rate by a third.

“We were surprised,” said Dr. Mette Kalager, the lead author of the paper who is a breast surgeon at Oslo University and a visiting scientist at the Harvard School of Public Health.

Marvin Zelen, a statistician at the Harvard School of Public Health and the Dana-Farber Cancer Institute, who was a member of the research team said even though the mammography benefit is small, if he were a woman he would get screened.

“It all depends on how you approach risk,” Dr. Zelen said. His approach, he says, is “minimax” ― he wants to minimize the maximum risk ― which, in this case, is dying of a cancer.

Dr. Kalager came to the opposite conclusion. She worries about the small chance of benefit in light of the larger chance of finding and treating a cancer that did not need to be treated.

“Since I’m a breast cancer surgeon, I know what being treated is like,” she says. The decision to be screened, she says, “is a matter of personal preference. Is it worth it to risk becoming a patient without it being necessary?”

Many women may still want mammograms, she says, and that is fine.

“I think we have to respect what women want to do.”

---------------------------------------------------
Effect of Screening Mammography on Breast-Cancer Mortality in Norway

Mette Kalager, M.D., Marvin Zelen, Ph.D., Fr?ydis Langmark, M.D., and Hans-Olov Adami, M.D., Ph.D.

N Engl J Med 2010; 363:1203-1210September 23, 2010


Background

A challenge in quantifying the effect of screening mammography on breast-cancer mortality is to provide valid comparison groups. The use of historical control subjects does not take into account chronologic trends associated with advances in breast-cancer awareness and treatment.

Methods

The Norwegian breast-cancer screening program was started in 1996 and expanded geographically during the subsequent 9 years. Women between the ages of 50 and 69 years were offered screening mammography every 2 years. We compared the incidence-based rates of death from breast cancer in four groups: two groups of women who from 1996 through 2005 were living in counties with screening (screening group) or without screening (nonscreening group); and two historical-comparison groups that from 1986 through 1995 mirrored the current groups.

Results

We analyzed data from 40,075 women with breast cancer. The rate of death was reduced by 7.2 deaths per 100,000 person-years in the screening group as compared with the historical screening group (rate ratio, 0.72; 95% confidence interval [CI], 0.63 to 0.81) and by 4.8 deaths per 100,000 person-years in the nonscreening group as compared with the historical nonscreening group (rate ratio, 0.82; 95% CI, 0.71 to 0.93; P<0.001 for both comparisons), for a relative reduction in mortality of 10% in the screening group (P=0.13). Thus, the difference in the reduction in mortality between the current and historical groups that could be attributed to screening alone was 2.4 deaths per 100,000 person-years, or a third of the total reduction of 7.2 deaths.

Conclusions

The availability of screening mammography was associated with a reduction in the rate of death from breast cancer, but the screening itself accounted for only about a third of the total reduction. (Funded by the Cancer Registry of Norway and the Research Council of Norway.)


テーマ

関連テーマ 一覧


月別リンク

ブログ気持玉

クリックして気持ちを伝えよう!
ログインしてクリックすれば、自分のブログへのリンクが付きます。
→ログインへ
気持玉数 : 1
なるほど(納得、参考になった、ヘー)

トラックバック(0件)

タイトル (本文) ブログ名/日時

トラックバック用URL help


自分のブログにトラックバック記事作成(会員用) help

タイトル
本 文

コメント(0件)

内 容 ニックネーム/日時

コメントする help

ニックネーム
本 文
乳がん検診マンモグラフィーの効用はわずか? 医師の一分/BIGLOBEウェブリブログ
文字サイズ:       閉じる