医師の一分

アクセスカウンタ

zoom RSS 父親の食生活が娘に影響/肥満

<<   作成日時 : 2010/10/21 20:38   >>

なるほど(納得、参考になった、ヘー) ブログ気持玉 1 / トラックバック 0 / コメント 0

 親の肥満が子どもの肥満のリスクとなる。不健康な食事をとる母親は代謝の問題を子どもに引き渡してしまうが、父親についてはわかっていなかった。人の場合は家庭環境が影響してしまうため解明が困難である。
 オーストラリアの研究者は高脂肪食を雄ラットに与え、健康食の雌ラットとの間に生まれた雌の子ラットについて調査した。出生体重は少なく、成長すると、太った父親と同じ脂肪・筋肉量・トリグリセリド・レプチンであった。さらに糖耐性とインスリン分泌に障害があった。健康問題は父親より早期に始まり悪化した。
 遺伝子分析によれば、インシュリンとグルコース代謝に関連した642個の遺伝子の発現が異なっていることが明らかとなった。インシュリンを作る膵臓β細胞の機能に影響していた。

-----------------------------------------------------
What a dad eats can affect his daughter's health, researchers
http://www.latimes.com/health/boostershots/la-heb-fat-dads-affect-daughters-20101020,0,134492.story

画像The rats whose dads ate the high-fat chow had impaired glucose tolerance and insulin secretion, the study found. (Robert Gauthier / Los Angeles Times)

la-heb-fat-dads-affect-daughters-20101020

Kids with obese parents are known to be at increased risk of childhood obesity themselves. Moms with unhealthy diets have been shown to pass along metabolic problems to their kids, but exactly how dads fit into the equation is unclear. In humans, this is particularly difficult because fathers and children often share not just genes, but a home environment as well.

Thankfully, we have rats to help sort this out.

Australian researchers fed some male rats a high-fat diet and kept others on a healthy diet. Both groups of rats mated with females, all of whom ate a healthy diet. Then the researchers studied the resulting female pups.

The pups born to overweight fathers were smaller than those with healthy fathers. When they grew up, the daughters of overweight fathers had the same amount of fat, muscle mass, triglycerides and leptin as daughters of healthy fathers. But there were differences -- the rats whose dads ate the high-fat chow had impaired glucose tolerance and insulin secretion. The problems started earlier than for rats with healthy dads, and they got worse over time.

Genetic analysis revealed that 642 genes related to insulin and glucose metabolism were expressed differently in the daughters of overweight rats compared with the control rats. These so-called epigenetic changes affected the function of pancreatic cells that make insulin.

“To our knowledge, this is the first direct demonstration in any species that a paternal environmental exposure” -- in this case, a high-fat diet -- “can induce intergenerational transmission of impaired glucose-insulin homeostatis in their female offspring.”

The findings will be published in Thursday’s edition of the journal Nature.

-- Karen Kaplan/Los Angeles Times

Copyright (c) 2010, Los Angeles Times

----------------------------------------------------
Nature 467, 963-966 (21 October 2010) | doi:10.1038/nature09491; Received 27 December 2009; Accepted 10 September 2010; Published online 20 October 2010

Chronic high-fat diet in fathers programs β-cell dysfunction in female rat offspring

Sheau-Fang Ng1, Ruby C. Y. Lin2, D. Ross Laybutt3, Romain Barres4, Julie A. Owens5 & Margaret J. Morris1

1. Department of Pharmacology, School of Medical Sciences, University of New South Wales, New South Wales, Sydney 2052, Australia
2. Ramaciotti Centre for Gene Function Analysis and School of Biotechnology and Biomolecular Sciences, University of New South Wales, New South Wales, Sydney 2052, Australia
3. Garvan Institute of Medical Research, 384 Victoria St, Darlinghurst, Sydney 2010, Australia
4. Department of Anatomy, School of Medical Sciences, University of New South Wales, New South Wales, Sydney 2052, Australia
5. School of Paediatrics and Reproductive Health, University of Adelaide, South Australia 5005, Australia

Correspondence to: Margaret J. Morris1 Email: m.morris@unsw.edu.au

Top of page
Abstract

The global prevalence of obesity is increasing across most ages in both sexes. This is contributing to the early emergence of type 2 diabetes and its related epidemic1, 2. Having either parent obese is an independent risk factor for childhood obesity3. Although the detrimental impacts of diet-induced maternal obesity on adiposity and metabolism in offspring are well established4, the extent of any contribution of obese fathers is unclear, particularly the role of non-genetic factors in the causal pathway. Here we show that paternal high-fat-diet (HFD) exposure programs β-cell ‘dysfunction’ in rat F1 female offspring. Chronic HFD consumption in Sprague--Dawley fathers induced increased body weight, adiposity, impaired glucose tolerance and insulin sensitivity. Relative to controls, their female offspring had an early onset of impaired insulin secretion and glucose tolerance that worsened with time, and normal adiposity. Paternal HFD altered the expression of 642 pancreatic islet genes in adult female offspring (P < 0.01); genes belonged to 13 functional clusters, including cation and ATP binding, cytoskeleton and intracellular transport. Broader pathway analysis of 2,492 genes differentially expressed (P < 0.05) demonstrated involvement of calcium-, MAPK- and Wnt-signalling pathways, apoptosis and the cell cycle. Hypomethylation of the Il13ra2 gene, which showed the highest fold difference in expression (1.76-fold increase), was demonstrated. This is the first report in mammals of non-genetic, intergenerational transmission of metabolic sequelae of a HFD from father to offspring.

1. Department of Pharmacology, School of Medical Sciences, University of New South Wales, New South Wales, Sydney 2052, Australia
2. Ramaciotti Centre for Gene Function Analysis and School of Biotechnology and Biomolecular Sciences, University of New South Wales, New South Wales, Sydney 2052, Australia
3. Garvan Institute of Medical Research, 384 Victoria St, Darlinghurst, Sydney 2010, Australia
4. Department of Anatomy, School of Medical Sciences, University of New South Wales, New South Wales, Sydney 2052, Australia
5. School of Paediatrics and Reproductive Health, University of Adelaide, South Australia 5005, Australia

Correspondence to: Margaret J. Morris1 Email: m.morris@unsw.edu.au

テーマ

関連テーマ 一覧


月別リンク

ブログ気持玉

クリックして気持ちを伝えよう!
ログインしてクリックすれば、自分のブログへのリンクが付きます。
→ログインへ
気持玉数 : 1
なるほど(納得、参考になった、ヘー)

トラックバック(0件)

タイトル (本文) ブログ名/日時

トラックバック用URL help


自分のブログにトラックバック記事作成(会員用) help

タイトル
本 文

コメント(0件)

内 容 ニックネーム/日時

コメントする help

ニックネーム
本 文
父親の食生活が娘に影響/肥満 医師の一分/BIGLOBEウェブリブログ
文字サイズ:       閉じる