医師の一分

アクセスカウンタ

zoom RSS ワクチンと自閉症の関連 研究はデータ偽造による/BMJ

<<   作成日時 : 2011/01/07 19:58   >>

なるほど(納得、参考になった、ヘー) ブログ気持玉 1 / トラックバック 0 / コメント 0

 ワクチンと自閉症が関連しているという研究発表をして資格を剥奪された英国医師アンドリュー・ウェークフィールド博士はデータを偽造していたとBMJに公表された。
 ミスを犯した可能性もなくはないが、データを偽造した可能性が高いと雑誌編集長は言う。カルテやインタビューを元に、偽造と判断したという。例えば、彼のレポートではわずか12人の子どもしか報告されておらず、数人はワクチン接種前から自閉症の症状があったとしている。
 ウェークフィールド氏は1998年に医学雑誌ランセットに、麻疹・流行性耳下腺炎・風疹(MMR)ワクチンと自閉症とが関連しているという研究結果を発表した。しかし、去年2月にランセットはこの論文を取り下げた。
 英国の医師審議会の規律委員会はウェークフィールドが「無責任で、不正直な」方法で研究を行い、医療専門職を不評に至らせたと発表した。
 多くの専門家がワクチンと自閉症の関係を証明しようとしてきた。最近では水銀系の防腐剤のチメロサールに疑いの目が向けられてきたが、いずれも明確な関係は証明できていない。
 WHOによれば、麻疹に1年に1000万人が感染して164,000人が死亡している。ワクチン接種で死者数を78%に減らせたという。

----------------------
ワクチンと自閉症に関連があるとした医師を資格停止に/英国医療事情
http://kurie.at.webry.info/201005/article_22.html
自閉症とMMRワクチンの関連論文 ランセットが撤回
http://kurie.at.webry.info/201002/article_4.html
麻疹流行の危険/英国医療事情
http://kurie.at.webry.info/200709/article_13.html
麻疹流行の深刻化/英国医療事情 はしか ワクチン
http://kurie.at.webry.info/200902/article_14.html
ワクチンと自閉症は関連なしと裁判所が断定/米国医療事情
http://kurie.at.webry.info/200902/article_29.html
---------------------------------------------------
Autism-vaccine researcher a "fraud": medical journal
http://www.reuters.com/article/idUSTRE7050J420110106

By Maggie Fox, Health and Science Editor
WASHINGTON | Thu Jan 6, 2011 5:14am EST

画像WASHINGTON (Reuters) - Dr. Andrew Wakefield, the-now disgraced British doctor who published studies linking vaccines with autism, committed an "elaborate fraud" by faking data, the British Medical Journal said on Wednesday.

The journal's editors said it was not possible that Wakefield made a mistake but must have falsified the data for his study, which convinced thousands of parents that vaccines are dangerous and which is blamed for ongoing outbreaks of measles and mumps.

The journal, commonly nicknamed the BMJ, supported its position with a series of articles by a journalist who used medical records and interviews to show that Wakefield falsified data.

For instance, the reports found that Wakefield, who included data from only 12 children in his report, studied at least 13 and that several showed symptoms of autism before having been vaccinated.

Fears that vaccines might cause autism have not only caused parents to skip vaccinating their children, but have forced costly reformulations of many vaccines.

"Who perpetrated this fraud? There is no doubt that it was Wakefield," BMJ editor Dr. Fiona Godlee and colleagues wrote in a commentary, available online here

In 1998, The Lancet medical journal, a rival to the BMJ, published a study by Wakefield and colleagues linking the combined measles, mumps and rubella (MMR) vaccine with autism.

The other researchers later withdrew their names from the study and The Lancet formally retracted the paper in February.

DENIAL

Wakefield denied the allegations.

"The study is not a lie. The findings that we have made have been replicated in five countries around the world," Wakefield told CNN television on Wednesday.

A disciplinary panel of Britain's General Medical Council said last February that Wakefield had presented his research in an "irresponsible and dishonest" way and had brought the medical profession into disrepute.

Godlee and colleagues said the work "was based not on bad science but on a deliberate fraud".

"Clear evidence of falsification of data should now close the door on this damaging vaccine scare," they added.

Many experts have tried to show that vaccines might cause autism. Newer suspicions have focused on thimerosal, a mercury-based preservative once used in many vaccines and since removed from childhood vaccines.

But no studies have shown any clear link. The U.S. Institute of Medicine has issued several reports saying not only is there no evidence of a link, but urging researchers to look elsewhere for possible causes of autism, which affects an estimated 1 in 110 children in the United States, according to the Centers for Disease Control and Prevention.

Measles is one of the most contagious viruses known, infecting 10 million people a year and killing 164,000, according to the World Health Organization.

Vaccination has reduced the number of measles deaths by 78 percent, WHO says. But refusal by some parents to get children vaccinated has helped fuel a resurgence in Britain.

In a 2007 U.S. outbreak, 127 people became ill and nearly half were children who had not been vaccinated because their parents objected, the CDC said. In 2009, an outbreak in Wales sickened more than 200 people

(Reporting by Maggie Fox, editing by Philip Barbara)

-----------------------------------------------------
BMJ 2011; 342:c5347 doi: 10.1136/bmj.c5347 (Published 5 January 2011)
Cite this as: BMJ 2011; 342:c5347

* Secrets of the MMR scare
How the case against the MMR vaccine was fixed


1. Brian Deer, journalist
1London, UK
1. briandeer.com

In the first part of a special BMJ series, Brian Deer exposes the bogus data behind claims that launched a worldwide scare over the measles, mumps, and rubella vaccine, and reveals how the appearance of a link with autism was manufactured at a London medical school

When I broke the news to the father of child 11, at first he did not believe me. “Wakefield told us my son was the 13th child they saw,” he said, gazing for the first time at the now infamous research paper which linked a purported new syndrome with the measles, mumps, and rubella (MMR) vaccine. 1 “There’s only 12 in this.”

That paper was published in the Lancet on 28 February 1998. It was retracted on 2 February 2010. 2 Authored by Andrew Wakefield, John Walker-Smith, and 11 others from the Royal Free medical school, London, it reported on 12 developmentally challenged children, 3 and triggered a decade long public health scare.

“Onset of behavioural symptoms was associated by the parents with measles, mumps, and rubella vaccination in eight of the 12 children,” began the paper’s “findings.” Adopting these claims as fact, 4 its “results” section added: “In these eight children the average interval from exposure to first behavioural symptoms was 6.3 days (range 1-14).”

Mr 11, an American engineer, looked again at the paper: a five page case series of 11 boys and one girl, aged between 3 and 9 years. Nine children, it said, had diagnoses of “regressive” autism, and all but one were reported with “non-specific colitis.” The “new syndrome” brought these together, linking brain and bowel diseases. His son was the penultimate case.

Running his finger across the paper’s tables, over coffee in London, Mr 11 seemed reassured by his anonymised son’s age and other details. But then he …

テーマ

関連テーマ 一覧


月別リンク

ブログ気持玉

クリックして気持ちを伝えよう!
ログインしてクリックすれば、自分のブログへのリンクが付きます。
→ログインへ
気持玉数 : 1
なるほど(納得、参考になった、ヘー)

トラックバック(0件)

タイトル (本文) ブログ名/日時

トラックバック用URL help


自分のブログにトラックバック記事作成(会員用) help

タイトル
本 文

コメント(0件)

内 容 ニックネーム/日時

コメントする help

ニックネーム
本 文
ワクチンと自閉症の関連 研究はデータ偽造による/BMJ 医師の一分/BIGLOBEウェブリブログ
文字サイズ:       閉じる