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zoom RSS 農場に住む子供は喘息やアトピーになりにくい

<<   作成日時 : 2011/02/24 20:17   >>

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 昔ながらの農場などのように様々な微生物に曝される環境で育った子どもは小児喘息やアトピーになりにくいという。
 喘息のリスクは農場に住む子供では51%も減り、研究者は、呼吸器疾患の予防は微生物への曝露の多様性にあると考えている。
 他の研究では、特に雌牛、ブタ、干し草にさらされる農場に住む子供が、喘息とアレルギーになりにくいとわかったという。
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妊娠中に微生物に曝された母親から生まれた子どもはアレルギーになりにくい
http://kurie.at.webry.info/200912/article_12.html
寄生虫によるアレルギー治療(2)
http://kurie.at.webry.info/200907/article_33.html
ピロリ菌が子どもの喘息を予防する?/米国
http://kurie.at.webry.info/200807/article_32.html


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Kids Growing Up on Farms Less Likely to Have Asthma
Study finds exposure to variety of barnyard microbes may lower risk of airway disease
By Serena GordonHealthDay Reporter
http://health.msn.com/health-topics/allergies/articlepage.aspx?cp-documentid=100270061

画像WEDNESDAY, Feb. 23 (HealthDay News) -- In a European study that echoes the findings of other scientists, researchers have found that children who grow up on farms are less likely to develop childhood asthma.

The risk of asthma was reduced by as much as 51 percent for children living on farms, and researchers suspect that it's the diversity of exposure to different microbes that may offer protection against the airway disease.

"The risk of asthma decreased with an increase in the diversity of microbial exposure," said study author Dr. Markus Ege, a researcher at Munich University Children's Hospital in Germany.

"Within the microbial spectrum under investigation, several germs with a potential for asthma prevention were identified," he added.

Results of the study are published in the Feb. 24 issue of the New England Journal of Medicine.

Asthma is a chronic lung disease that causes inflammation of the airways. This inflammation narrows the airways, making it difficult to breathe. Symptoms include wheezing, coughing, chest pain and tightness, and shortness of breath, according to the National Heart, Lung, and Blood Institute (NHLBI).

The exact cause of asthma remains unknown. People with a family history of the disease are more likely to develop asthma, suggesting a possible genetic component to the disease. But environmental exposures, such as encountering certain viruses, are also associated with the development of the condition, according to the NHLBI.

Numerous studies have also found that exposure to a variety of microbes in the environment, such as bacteria or fungi, appear to provide protection against asthma, perhaps by helping the body create a tolerance for allergens.

And, other research has found that children living on farms -- especially those exposed to cows, pigs and hay -- seem to be less likely to have asthma and allergies.

Exactly how exposure to a variety of microbes might protect against asthma is still unclear, researchers noted.

"How these microorganisms reduce the asthma risk remains largely unknown," said Ege. "A combination of environmental microorganisms might stimulate the innate immune system and counterbalance an asthma-prone immune status. Alternatively, the diversity of microbial exposure might prevent specific [disease-causing] microorganisms with an asthma-inducing potential."

The current study assessed the incidence of asthma in children living on farms compared to children without farm exposure in two different groups of youngsters. The researchers also tested dust samples from the children's bedrooms and mattresses to get an idea of what type of microbes the children were regularly exposed to.

The first group of children included 6,843 rural and suburban elementary school children from southern Germany. This study, dubbed PARSIFAL, also included dust samples from 489 children's mattresses. The second study, called GABRIELA, included 9,668 elementary school kids from rural areas of Austria, South Germany and Switzerland. Dust samples were collected from 444 children's bedrooms in this study.

House dust from farm homes had a greater variety of bacteria and fungi, a finding that was statistically related to a lower rate of asthma.

In both study populations, youngsters who lived on farms had lower rates of asthma and allergies, according to the study. In the PARSIFAL group, the risk of asthma was reduced by 51 percent in children living on farms. In GABRIELA, the reduction was 24 percent, according to Ege.

The researchers also found that diversity of microbial exposure lowered the odds of asthma by 38 percent in the PARSIFAL population and by 14 percent in GABRIELA, according to the study.

"Not all microbes are detrimental; some are beneficial for asthma and allergies," explained Ege. But, he cautioned that this doesn't mean that dirt or microbes in general should be considered healthy, or that parents should try to deliberately expose their children to microbes.

"There are enormous numbers of different microorganisms which affect human health by various measures and in opposite directions. There are still dangerous infections, which should be prevented by vaccination or treated with antibiotics," Ege stressed.

One expert who wrote an accompanying editorial in the same journal noted that it was "of critical importance" to figure out how microbe exposure affects the biology of the lungs and immune system.

"This study shows that kids who grow up on farms are less likely to develop asthma, but I don't think there's anything that can be applied to treatment right now," said Dr. James Gern, a professor of pediatrics and medicine at the University of Wisconsin School of Medicine and Public Health in Madison.

"As we learn more about what these protective exposures are," he said, "it's possible we could come up with ways to prevent asthma in the future."

More information

Read more about the causes of asthma from the National Heart, Lung, and Blood Institute.
SOURCES: Markus Ege, M.D., M.P.H., researcher, Munich University Children's Hospital, Germany; James E. Gern, professor, pediatrics and medicine, University of Wisconsin School of Medicine and Public Health, Madison; Feb. 24, 2011, New England Journal of Medicine

Copyright @2011 HealthDay. All Rights Reserved.

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Exposure to Environmental Microorganisms and Childhood Asthma

Markus J. Ege, M.D., Melanie Mayer, Ph.D., Anne-Ce'cile Normand, Ph.D., Jon Genuneit, M.D., William O.C.M. Cookson, M.D., D.Phil., Charlotte Braun-Fahrla"nder, M.D., Dick Heederik, Ph.D., Renaud Piarroux, M.D., Ph.D., and Erika von Mutius, M.D. for the GABRIELA Transregio 22 Study Group

N Engl J Med 2011; 364:701-709February 24, 2011

Background

Children who grow up in environments that afford them a wide range of microbial exposures, such as traditional farms, are protected from childhood asthma and atopy. In previous studies, markers of microbial exposure have been inversely related to these conditions.

Full Text of Background...
Methods

In two cross-sectional studies, we compared children living on farms with those in a reference group with respect to the prevalence of asthma and atopy and to the diversity of microbial exposure. In one study ― PARSIFAL (Prevention of Allergy ― Risk Factors for Sensitization in Children Related to Farming and Anthroposophic Lifestyle) ― samples of mattress dust were screened for bacterial DNA with the use of single-strand conformation polymorphism (SSCP) analyses to detect environmental bacteria that cannot be measured by means of culture techniques. In the other study ― GABRIELA (Multidisciplinary Study to Identify the Genetic and Environmental Causes of Asthma in the European Community [GABRIEL] Advanced Study) ― samples of settled dust from children's rooms were evaluated for bacterial and fungal taxa with the use of culture techniques.

Full Text of Methods...
Results

In both studies, children who lived on farms had lower prevalences of asthma and atopy and were exposed to a greater variety of environmental microorganisms than the children in the reference group. In turn, diversity of microbial exposure was inversely related to the risk of asthma (odds ratio for PARSIFAL, 0.62; 95% confidence interval [CI], 0.44 to 0.89; odds ratio for GABRIELA, 0.86; 95% CI, 0.75 to 0.99). In addition, the presence of certain more circumscribed exposures was also inversely related to the risk of asthma; this included exposure to species in the fungal taxon eurotium (adjusted odds ratio, 0.37; 95% CI, 0.18 to 0.76) and to a variety of bacterial species, including Listeria monocytogenes, bacillus species, corynebacterium species, and others (adjusted odds ratio, 0.57; 95% CI, 0.38 to 0.86).


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