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<<   作成日時 : 2012/01/18 23:52   >>

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魚油サプリが高齢者の筋力を高める
小規模な臨床試験ではあるが、高齢女性が運動に加えて魚油のサプリメントを服用することで筋力を向上させる可能性があるとの結果がでた。
 60台の健康な女性は3ヶ月の運動により筋力が増強し、2gの魚油サプリを摂ることで更に効果がえられた。筋力の増強が日常生活にどれほど有意義かは不明であり、コストの問題や副作用の可能性は残っている。
 米国では、魚油カプセル1gで月15ドル以上となる。魚油は、一般的に推奨される用量では安全と見なされているが、よくある副作用として口臭、胸焼け、吐き気、軟便などがある。NIHによれば、1日3g以上では、血液凝固が阻害されて出血のリスクが高まるとされている。

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Fish oil plus exercise may do older muscles good
http://www.reuters.com/article/2012/01/17/us-fish-oil-idUSTRE80G2AP20120117

By Amy Norton
NEW YORK | Tue Jan 17, 2012 5:38pm EST
(Reuters Health) - Older women may be able to boost their muscle strength by adding fish oil supplements to their exercise routine, a small clinical trial suggests.

Researchers found that three months of strength training helped increase muscle strength among 45 healthy women in their 60s. But those who used fish oil at the same time had somewhat greater gains.

Whether older women should run out to buy fish oil for the sake of their muscles remains to be seen.

It's not clear whether the extra strength gain would be meaningful in a woman's life -- and, therefore, worth the cost and potential side effects of fish oil pills.

The findings are "intriguing" and deserve further study, said Catherine Jackson, a professor of kinesiology at California State University in Fresno who was not involved in the study.

But, she told Reuters Health in an email, "I would be a bit cautious about over-interpretation."

The researchers themselves echoed that thought. The findings "should be viewed with caution," according to Luiz Claudio Fernandes and colleagues at Parana Federal University in Brazil.

"Other studies involving a larger sample and other combinations of training and supplementation period are required," they write in the American Journal of Clinical Nutrition.

WHAT DOES FISH OIL DO?

Fish oil, which is rich in omega-3 fatty acids, is probably best known for its link to heart health. Fish oil supplements can lower triglycerides (a type of blood fat), and people who get more omega-3 have been found to have a lower risk of heart disease.

But there's also evidence that fish oil can improve nerve function and the ability of heart muscle to contract. So it's "reasonable to hypothesize" that fish oil could boost muscles' response to strengthening exercises, according to Fernandes' team.

To study the question, the researchers randomly assigned 45 older women to one of three exercise groups: In one, the women performed strengthening exercise three times a week for three months; the other two groups followed the same regimen, but also took fish oil -- 2 grams per day, either starting on the same day as their exercise program, or starting two months beforehand.

On average, all three groups increased their muscle strength, which was measured in tests where the women contracted their leg muscles. But the change was greater in the two fish-oil groups.

On top of that, only women who used fish oil showed changes in nerve activity in the muscles.

Exactly what that all means for women's well-being is not clear.

One issue, Jackson said, is that "strength measurement is difficult at best and shows huge differences among subjects."

The study participants did take four "functional" tests that gauged strength, balance, agility and how far they could walk in 6 minutes. And women using fish oil did slightly better on one of those tests -- where they had to sit down and rise up from a chair several times in a row, as fast as they could.

Whether any of that could translate into better fitness, a lower risk of falls or other health benefits is unknown for now.

A question with any supplement study, Jackson noted, is whether users were "deficient" in a nutrient -- omega-3 fats, in this case -- to begin with. If so, the supplement might have brought them to a more "normal" level, and the benefit of a supplement beyond a healthful, balanced diet would be unclear.

In the U.S., a monthly supply of one-gram fish oil capsules can run well over $15.

And while fish oil is generally considered safe at recommended doses, it can have side effects; the more common side effects include bad breath, heartburn, nausea and loose stools.

At higher doses -- more than 3 grams per day -- fish oil might interfere with blood clotting and raise the risk of internal bleeding, according to the National Institutes of Health.

People using medications -- as most older adults are -- should also check with their doctor about possible interactions. Fish oil can, for example, boost the effects of blood pressure drugs, which could send your blood pressure too low.

SOURCE: bit.ly/AnRGII American Journal of Clinical Nutrition, January 4, 2012.

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First published January 4, 2012, doi: 10.3945/?ajcn.111.021915
Am J Clin Nutr February 2012 ajcn.021915

Fish-oil supplementation enhances the effects of strength training in elderly women1,2,3
Cintia LN Rodacki, Andre LF Rodacki, Gleber Pereira, Katya Naliwaiko, Isabela Coelho, Daniele Pequito, and Luiz Cleudio Fernandes
+ Author Affiliations

1From Parana Federal University, Setor de Ciencias Biologicas, Curitiba, Parana, Brazil (CLNR, ALFR, KN, IC, DP, and LCF), and Positivo University, Nucleus of Biological and Health Science, Curitiba, Parana, Brazil (CLNR and GP).
+ Author Notes

?2 There was no funding source in this study. Fish oil was kindly donated by Herbarium Foundation for Health and research, Curitiba, Parana, Brazil.

?3 Address correspondence to ALF Rodacki, R. Coracao de Maria, 92?Jardim Botanico?Curitiba, Parana, Brazil. E-mail: rodacki@ufpr.br.

Abstract

Background: Muscle force and functional capacity generally decrease with aging in the older population, although this effect can be reversed, attenuated, or both through strength training. Fish oil (FO), which is rich in n?3 (omega-3) PUFAs, has been shown to play a role in the plasma membrane and cell function of muscles, which may enhance the benefits of training. The effect of strength training and FO supplementation on the neuromuscular system of the elderly has not been investigated.

Objective: The objective was to investigate the chronic effect of FO supplementation and strength training on the neuromuscular system (muscle strength and functional capacity) of older women.

Design: Forty-five women (aged 64 ± 1.4 y) were randomly assigned to 3 groups. One group performed strength training only (ST group) for 90 d, whereas the others performed the same strength-training program and received FO supplementation (2 g/d) for 90 d (ST90 group) or for 150 d (ST150 group; supplemented 60 d before training). Muscle strength and functional capacity were assessed before and after the training period.

Results: No differences in the pretraining period were found between groups for any of the variables. The peak torque and rate of torque development for all muscles (knee flexor and extensor, plantar and dorsiflexor) increased from pre- to posttraining in all groups. However, the effect was greater in the ST90 and ST150 groups than in the ST group. The activation level and electromechanical delay of the muscles changed from pre- to posttraining only for the ST90 and ST150 groups. Chair-rising performance in the FO groups was higher than in the ST group.

Conclusions: Strength training increased muscle strength in elderly women. The inclusion of FO supplementation caused greater improvements in muscle strength and functional capacity.

Received June 16, 2011.
Accepted November 21, 2011.

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