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<<   作成日時 : 2012/12/24 23:24   >>

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コーヒーが口腔がん死亡リスク低下に関連
画像 全く飲まない人に比べて1日4〜6杯のコーヒーを飲む人は、口腔咽頭がんの死亡リスクが50%も低かった。
 リスク低下とカフェイン抜きのコーヒーとはかろうじて関連あったが、紅茶との関連はなかった。
 機序は不明だがコーヒーは抗がん作用を有する化合物を含んでいる可能性がある。

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Risks: Coffee Linked to Fewer Oral Cancer Deaths
By NICHOLAS BAKALAR

http://well.blogs.nytimes.com/2012/12/17/risks-coffee-linked-to-fewer-oral-cancer-deaths

A large study has found that drinking coffee is associated with a reduced risk of death from oral cancer.

Researchers studied 968,432 initially healthy men and women beginning in 1982. All completed questionnaires on health and dietary habits, including amounts of tea and coffee consumed, at the start of the study period. Twenty-six years later, 868 people had died of oral or throat cancer.

After adjusting for smoking, alcohol consumption and other factors, the researchers found that the risk of death from oral or throat cancer was 26 percent lower among those who drank one cup a day, 33 percent lower among those who drank two to three cups daily, and 50 percent lower among those who drank four to six cups daily, compared with those who drank no caffeinated coffee.

There was a barely significant association of decaffeinated coffee with reduced risk, and no link at all to tea. The report was posted online this month in The American Journal of Epidemiology.

The authors acknowledge that they could not distinguish whether coffee drinkers were less likely to get oral or throat cancer or more likely to survive it. The lead author, Janet S. Hildebrand of the American Cancer Society, said that the mechanism was unclear, but that coffee contains compounds that may have anticancer effects.

“We are not recommending that people start drinking coffee for cancer prevention,” she said. “But this is good news for those of us who enjoy coffee.”

This post has been revised to reflect the following correction:

Correction: December 19, 2012

A report in the Vital Signs column on Tuesday about drinking coffee and the risk of death from oral cancer misstated part of the name of an organization involved in a recent study. It is the American Cancer Society, not the National Cancer Society.

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Coffee, Tea, and Fatal Oral/Pharyngeal Cancer in a Large Prospective US Cohort
Janet S. Hildebrand*, Alpa V. Patel, Marjorie L. McCullough, Mia M. Gaudet, Amy Y. Chen, Richard B. Hayes and Susan M. Gapstur

Am. J. Epidemiol. (2012)
doi: 10.1093/aje/kws222
First published online: December 9, 2012

?*Correspondence to Janet S. Hildebrand, Epidemiology Research Program, American Cancer Society, 250 Williams Street NW, Atlanta, GA 30303 (e-mail: janet.hildebrand@cancer.org).
Abbreviations: CI, confidence interval; HPV, human papillomavirus; RR, relative risk.

Received November 23, 2011.
Accepted April 16, 2012.
Abstract

Epidemiologic studies suggest that coffee intake is associated with reduced risk of oral/pharyngeal cancer. The authors examined associations of caffeinated coffee, decaffeinated coffee, and tea intake with fatal oral/pharyngeal cancer in the Cancer Prevention Study II, a prospective US cohort study begun in 1982 by the American Cancer Society. Among 968,432 men and women who were cancer free at enrollment, 868 deaths due to oral/pharyngeal cancer occurred during 26 years of follow-up. Cox proportional hazards regression was used to estimate multivariable-adjusted relative risk. Intake of >4 cups/day of caffeinated coffee was associated with a 49% lower risk of oral/pharyngeal cancer death relative to no/occasional coffee intake (relative risk = 0.51, 95% confidence interval: 0.40, 0.64) (1 cup/day = 237 ml). A dose-related decline in relative risk was observed with each single cup/day consumed (Ptrend < 0.001). The association was not modified by sex, smoking status, or alcohol use. An inverse association for >2 cups/day of decaffeinated coffee intake was suggested (relative risk = 0.61, 95% confidence interval: 0.37, 1.01). No association was found for tea drinking. In this large prospective study, caffeinated coffee intake was inversely associated with oral/pharyngeal cancer mortality. Research is needed to elucidate biologic mechanisms whereby coffee might help to protect against these often fatal cancers.

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