医師の一分

アクセスカウンタ

zoom RSS 睡眠が記憶にはたす役割

<<   作成日時 : 2014/06/06 00:33   >>

ブログ気持玉 0 / トラックバック 0 / コメント 0

睡眠が記憶にはたす役割が判明
 睡眠中のマウスは神経細胞同士の結合が増加、徐波睡眠中におこっている。


-----------------------------------------------------
5 June 2014 Last updated at 23:44
Sleep's memory role discovered
By James Gallagher
Health and science reporter, BBC News
http://www.bbc.com/news/health-27695144

The mechanism by which a good night's sleep improves learning and memory has been discovered by scientists.

The team in China and the US used advanced microscopy to witness new connections between brain cells - synapses - forming during sleep.
Their study, published in the journal Science, showed even intense training could not make up for lost sleep.
Experts said it was an elegant and significant study, which uncovered the mechanisms of memory.
It is well known that sleep plays an important role in memory and learning. But what actually happens inside the brain has been a source of considerable debate.
Researchers at New York University School of Medicine and Peking University Shenzhen Graduate School trained mice in a new skill - walking on top of a rotating rod.
They then looked inside the living brain with a microscope to see what happened when the animals were either sleeping or sleep deprived.
Their study showed that sleeping mice formed significantly more new connections between neurons - they were learning more.

And by disrupting specific phases of sleep, the research group showed deep or slow-wave sleep was necessary for memory formation.
During this stage, the brain was "replaying" the activity from earlier in the day.
Prof Wen-Biao Gan, from New York University, told the BBC: "Finding out sleep promotes new connections between neurons is new, nobody knew this before.
"We thought sleep helped, but it could have been other causes, and we show it really helps to make connections and that in sleep the brain is not quiet, it is replaying what happened during the day and it seems quite important for making the connections."

-----------------------------------------------------
Science 6 June 2014:
Vol. 344 no. 6188 pp. 1173-1178
DOI: 10.1126/science.1249098
REPORT
Sleep promotes branch-specific formation of dendritic spines after learning
Guang Yang1,2, Cora Sau Wan Lai1, Joseph Cichon1, Lei Ma1,3, Wei Li3, Wen-Biao Gan1,*

How sleep helps learning and memory remains unknown. We report in mouse motor cortex that sleep after motor learning promotes the formation of postsynaptic dendritic spines on a subset of branches of individual layer V pyramidal neurons. New spines are formed on different sets of dendritic branches in response to different learning tasks and are protected from being eliminated when multiple tasks are learned. Neurons activated during learning of a motor task are reactivated during subsequent non?rapid eye movement sleep, and disrupting this neuronal reactivation prevents branch-specific spine formation. These findings indicate that sleep has a key role in promoting learning-dependent synapse formation and maintenance on selected dendritic branches, which contribute to memory storage.

テーマ

関連テーマ 一覧


月別リンク

ブログ気持玉

クリックして気持ちを伝えよう!
ログインしてクリックすれば、自分のブログへのリンクが付きます。
→ログインへ

トラックバック(0件)

タイトル (本文) ブログ名/日時

トラックバック用URL help


自分のブログにトラックバック記事作成(会員用) help

タイトル
本 文

コメント(0件)

内 容 ニックネーム/日時

コメントする help

ニックネーム
本 文
睡眠が記憶にはたす役割 医師の一分/BIGLOBEウェブリブログ
文字サイズ:       閉じる