乳児のはしか抗体価の低下 /麻疹はしか

画像 はしか流行反復のない世代の母親から生まれた乳児のはしか抗体価は低下している。

 母親から抗体をもらうため、1才までの乳児は麻疹(はしか)にはふつう罹患しないと言われている。しかしこれは母親がはしかに自然感染し、はしかの流行に繰り返し暴露されてきたおかげであるらしい。

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Scand J Infect Dis. 1999;31(1):17-9.
Reduced passive measles immunity in infants of mothers who have not been exposed to measles outbreaks.
Ohsaki M, Tsutsumi H, Takeuchi R, Kuniya Y, Chiba S.
Department of Pediatrics, Sapporo Medical University School of Medicine, Japan.
Natural measles infection usually confers life-long immunity which is transferred from mothers to their offspring, protecting them from natural measles until the age of about 12 months. Recently, however, natural measles has been observed with increased frequency in infants under the age of 12 months. Natural measles outbreaks in the city of Sapporo have been suppressed by widely applied measles vaccination. Passive measles immunity in 160 neonates (cord blood), born during the last 17 y in Sapporo, Japan was determined by a neutralization (NT) antibody test. The mothers of these infants had had natural measles infection during childhood. Geometric mean titres (GMTs) of cord blood NT antibodies gradually decreased after 1989 and the GMTs of the most recently born infants were significantly lower than those of infants born in the first few years of the study. These observations suggest that even in mothers who experienced natural measles in childhood, recurrent exposure to natural measles is necessary in order to maintain adequate antibody levels for effective passive immunity of their infants.
PMID: 10381212 [PubMed - indexed for MEDLINE]

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