ブロッコリが肺を守る

 ブロッコリで発見された物質が、重大な肺疾患による障害を軽減する可能性がある。
 慢性閉塞性肺疾患(COPD)は、しばしば喫煙により発症し、年に約30,000人の英国人が死亡している。sulforapaneが、毒素によって起こされた障害から細胞を保護する働きのある肺細胞内NRF2遺伝子の活動を増大させるとわかった。
 ブロッコリに含まれる化合物は、最近、糖尿病性血管障害に対して保護する働きがあることが発見された。ブロッコリなどのアブラナ属野菜はまた心臓発作と卒中のより低いリスクと関連している。
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ブロッコリーが前立腺癌を予防する
http://kurie.at.webry.info/200708/article_3.html
ブロッコリが糖尿病性血管障害を回復させる可能性
http://kurie.at.webry.info/200808/article_12.html
ブロッコリが心臓病に有効
http://kurie.at.webry.info/200801/article_46.html
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Page last updated at 23:05 GMT, Friday, 12 September 2008 00:05 UK
Broccoli 'may help protect lungs'
http://news.bbc.co.uk/2/hi/health/7612813.stm

画像Broccoli
Sulforapane is found in broccoli and brussel sprouts

A substance found in broccoli may limit the damage which leads to serious lung disease, research suggests.

Chronic obstructive pulmonary disease (COPD) is often caused by smoking and kills about 30,000 UK residents a year.
US scientists found that sulforapane increases the activity of the NRF2 gene in human lung cells which protects cells from damage caused by toxins.
The same broccoli compound was recently found to be protective against damage to blood vessels caused by diabetes.
Brassica vegetables such as broccoli have also been linked to a lower risk of heart attacks and strokes.

Cell pollutants
In the latest study, a team from John Hopkins School of Medicine found significantly lower activity of the NRF2 gene in smokers with advanced COPD.
Writing in the American Journal of Respiratory and Critical Care Medicine, they said the gene is responsible for turning on several mechanisms for removing toxins and pollutants which can damage cells.

We know broccoli naturally contains important compounds but studies so far have taken place in the test tube and further research is needed to find if you can produce the same effect in humans
Spokeswoman, British Lung Foundation

Previous studies in mice had shown that disrupting the NRF2 gene caused early onset severe emphysema - one of the conditions suffered by COPD patients.
Increasing the activity of NRF2 may lead to useful treatments for preventing the progression of COPD, the researchers said.
In the study, they showed that sulforapane was able to restore reduced levels of NRF2 in cells exposed to cigarette smoke.
"Future studies should target NRF2 as a novel strategy to increase antioxidant protection in the lungs and test its ability to improve lung function in people with COPD," said study leader Dr Shyam Biswal.
A spokeswoman for the British Lung Foundation said: "This is an important study for the 3 million people in the UK with COPD because of its findings about the imbalance of oxidants and antioxidants in the lungs.
"We know broccoli naturally contains important compounds but studies so far have taken place in the test tube and further research is needed to find if you can produce the same effect in humans."

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Peter J. Barnes
Defective Antioxidant Gene Regulation in COPD: A Case for Broccoli
Am. J. Respir. Crit. Care Med. 2008; 178: 552-554

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