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zoom RSS 1日2杯のワインがアルツハイマー病を予防する

<<   作成日時 : 2009/07/15 01:08   >>

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画像 1日2杯のワインがアルツハイマー病を予防すると国際会議で発表された。6年間にわたり痴呆症のリスクを37%減少させるという。
 アルコールそのものは痴呆症に影響を及ぼさないが、ライフスタイルがリスクに関連している。過度なアルコール消費は痴呆症や他の疾患と関連するため、2杯以上飲むことは許可しない。(ABC)
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 1週間で8-14杯のアルコールを飲む人が37%リスクが低かった。1週間で14杯以上飲む人は2倍の発症リスクとなる。Wake Forest Universityの研究で、75才以上の3,069人を6年間追跡し、最初482人が軽度認知症であったが、研究期間中に523人が新たに痴呆症を発症した。(BBC)
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Can Wine Fight Dementia?
A Glass a Day in the Golden Years May Protect Against Dementia, Study Says
http://abcnews.go.com/Health/MindMoodNews/story?id=8070552
By ED SUSMAN
MedPage Today Staff Writer
July 13, 2009

A glass or two of wine a day -- but no more -- appears to protect older adults from developing dementia, researchers reported here at the International Conference on Alzheimer's Disease.
A Little Vino ? But Not Too Much -- May Fight Dementia
A glass or two of wine a day -- but no more -- appears to protect older adults from developing dementia, researchers reported here at the International Conference on Alzheimer's Disease.
(Riser/Getty Images)

"Among cognitively normal older adults, one to two alcoholic drinks a day is associated with a 37 percent decreased risk of dementia over 6 years," said Dr. Kaycee Sink, a gerontologist at Wake Forest University School of Medicine.

These "moderate drinkers," who were at least 75 years old, had a lower risk of dementia than peers who abstained completely or those who had more than two drinks a day, Sink and her colleagues found.

However, she said she would not recommend that non-drinkers begin to use alcohol to try to prevent dementia.

Dr. Sink also said that her research found that patients who had been diagnosed with mild cognitive impairment did worse with any level of alcohol intake.

"Physicians need to be clear with their patients exactly what is meant by 'light,' 'moderate' and 'heavy' drinking," said Dr. Maria Carrillo, director of medical and scientific relations at the Alzheimer's Association, which sponsored the Vienna meeting.

In Sink's study, a light drinker consumed one drink or less of alcohol a day, while moderate consumption was one to two drinks. Heavy drinking involved more than two drinks a day.

Carrillo said that future studies would help the association decide whether to issue recommendations on alcohol consumption for prevention of dementia, or as part of a treatment scheme for patients with mild cognitive impairment.

She said it's possible that alcohol itself has no impact on dementia, but may reflect a lifestyle that results in more or less risk for dementia and other illnesses.

"This study does not give license to drink beyond one or two alcoholic beverages a day, since excessive alcohol consumption is associated with alcoholic dementia and other medical problems. And some people think if a little bit is good, more is better," cautioned Dr. Scott Turner, director of the Memory Disorders Program at Georgetown University.

A Little Wine May Protect Against Dementia

In the study, the researchers identified 3,069 participants in the Ginkgo Evaluation of Memory Study who were age 75 or older. They had undergone a complete assessment of cognition at the start of the study, evaluated for cognitive status at six-month intervals, and then were followed for about six years.

During the study, 388 cases of dementia occurred among the participants originally classified as normal, and 188 cases were diagnosed among patients who had mild cognitive impairment at baseline.

At the outset, 1,286 volunteers were teetotalers, 55.7 percent of whom were women. Of those who drank alcohol, 39.1 percent were women. More abstainers ( 20.2 percent) were classified as having mild cognitive impairment at baseline than alcohol consumers (12.3 percent).

After five years in the study, the 2,587 normal individuals who were self-reported moderate drinkers had a 37 percent reduced risk of developing dementia when compared with the abstainers -- the group most at risk of developing dementia.

However, when the researchers scrutinized development of dementia among the 482 patients with mild cognitive impairment at baseline, they found that heavy drinkers had nearly double the risk of dementia as abstainers.

Neither Sink, Carrillo nor Turner reported any conflicts of interest.

This article was prepared in collaboration with ABC News.

------------------------------------------------------
Page last updated at 09:10 GMT, Monday, 13 July 2009 10:10 UK
A few drinks 'cuts dementia risk'
http://news.bbc.co.uk/2/hi/health/8144149.stm

Red wine
The easy way to ward off dementia?

Older people who drink moderate amounts of alcohol may have a lower risk of dementia, a US study suggests.

Researchers found people who consumed between eight and 14 alcoholic drinks a week had a 37% lower risk of the disease than the general population.

However, people who consumed more than 14 drinks a week were at twice the normal risk of developing dementia.

The Wake Forest University study was presented at the International Conference on Alzheimer's Disease.


Older people with memory problems should consider not drinking at all
Rebecca Wood
Alzheimer's Research Trust

The US researchers focused on 3,069 people aged 75 or older.

At the beginning of the six-year study, 2,587 participants had no signs of problems with their brain while 482 had mild cognitive impairment. During the study 523 new dementia cases emerged.

The researchers took account of factors such as smoking, depression and social activity, and found that one or two drinks a day was associated with a 37% lower risk of dementia among those who were cognitively normal at the start of the study.

However, among those who already had mild cognitive impairment alcohol intake was associated with faster cognitive decline.

Among the people in the study, four in ten did not drink alcohol, four in ten consumed up to seven drinks a week, one in ten consumed 8-14 drinks a week, and one in ten consumed more than 14 drinks a week.

Reason not clear

Why a moderate amount of alcohol seems to be good for the brain is not clear.

Lead researcher Dr Kaycee Sink said: "There are several possible ways in which moderate drinking might be associated with reduced risk of dementia.

"One is the same as the way we think moderate alcohol reduces the risk of heart disease, by beneficial effects on HDL cholesterol and blocking platelets.

"Additionally, animal studies have shown that low amounts of alcohol stimulate the release of acetylcholine, a chemical in the brain that is important in memory."

Dr Sink added: "We cannot recommend that older adults who don't drink start drinking alcohol based on this study.

"But it is reasonable to say that if you are already a light to moderate drinker, you may be at a lower risk of developing Alzheimer's disease or other dementias.

"However, if you already have memory or thinking problems, drinking alcohol may accelerate memory decline."

Rebecca Wood, chief executive of the Alzheimer's Research Trust, said: "Although moderate alcohol intake does appear to reduce dementia risk, exceeding one to two drinks per day on a regular basis - becoming a heavy drinker - may double risk of developing dementia.

"On the basis of this study, older people with memory problems should consider not drinking at all.

"The best way to reduce dementia risk is to eat a balanced diet, exercise regularly and remain socially active."

The results conflict with those from a small study published in Neurology in 2007, which suggests people with mild cognitive impairment might slow their mental decline with up to one drink a day.

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