カレーを食べてアルツハイマー病や認知症を予防

 週に1-2回カレーを食べるとアルツハイマー病や痴呆の発症を防げるという。
 重要成分はウコンの成分のクルクミンである。クルクミンは痴呆を引きおこすと考えられているアミロイド蛋白斑が広がるのを防止するようである。
 ノースカロライナのデューク大Murali Doraiswamy教授は、週に2-3回カレー食をとる人々が痴呆症の発症リスクが低いという証拠があると言う。より多量の摂取での効果をみる研究をしている。
 クルクミンがアミロイド班に結合するという明白な証拠があるのでマウスでの研究が行われている。
 マウスを操作して12ヶ月で脳がアミロイド班でいっぱいになるようにできる。クルクミンを充分含んだ食事をマウスに与えるとアミロイド斑を溶かす。若いマウスの場合新しくアミロイド斑ができるのを防いだ。
 アルツハイマー病患者に対して現在臨床試験が進行中であるという。ガンや関節炎についても治療の可能性を調査中である。貧しい食事ではこうした効果は得られない。良い食事に運動とカレーで痴呆防止に役立つとDoraiswamy教授は言う。
 しかし、Rebecca Woodは、動物実験でのクルクミン量は、人では100gのカレー粉を食べる必要があると言う。
 インドではアルツハイマー病の発症は極めて少ないという。
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Page last updated at 09:45 GMT, Wednesday, 3 June 2009 10:45 UK
Weekly curry 'may fight dementia'
http://news.bbc.co.uk/2/hi/health/8080630.stm

画像Curry
The key ingredient appears to be turmeric

Eating a curry once or twice a week could help prevent the onset of Alzheimer's disease and dementia, a US researcher suggests.

The key ingredient is curcumin, a component of the spice turmeric.
Curcumin appears to prevent the spread of amyloid protein plaques - thought to cause dementia - in the brain.
But the theory, presented at the Royal College of Psychiatrists' annual meeting, has been given a lukewarm reception by UK experts.

If you have a good diet and take plenty of exercise, eating curry regularly could help prevent dementia
Professor Murali Doraiswamy
Duke University

Amyloid plaques, along with tangles of nerve fibres, are thought to contribute to the degradation of the wiring in brain cells, eventually leading to symptoms of dementia.
Professor Murali Doraiswamy, of Duke University in North Carolina, said there was evidence that people who eat a curry meal two or three times a week have a lower risk of dementia.
He said researchers were testing the impact of higher doses - the equivalent of going on a curry spree for a week - to see if they could maximise the effect.

Animal studies
Professor Doraiswamy told the meeting: "There is very solid evidence that curcumin binds to plaques, and basic research on animals engineered to produce human amyloid plaques has shown benefits."
"You can modify a mouse so that at about 12 months its brain is riddled with plaques.
"If you feed this rat a curcumin-rich diet it dissolves these plaques. The same diet prevented younger mice from forming new plaques.
"The next step is to test curcumin on human amyloid plaque formation using newer brain scans and there are plans for that."
Professor Doraiswamy said a clinical trial was now underway at the University of California, Los Angeles, to test curcumin's effects in Alzheimer's patients.
He said research had also examined turmeric's therapeutic potential for treating conditions such as cancer and arthritis.

Good diet
He stressed that eating a curry could not counter-balance the increased risk of dementia associated with a poor diet.

Indian communities that regularly eat curcumin have a surprisingly low incidence of Alzheimer's disease but we don't yet know why
Dr Susanne Sorensen
Alzheimer's Society

However, he said: "If you have a good diet and take plenty of exercise, eating curry regularly could help prevent dementia."
Professor Doraiswamy predicted it might be possible to develop a curry pill which had the same therapeutic effect.
However, Rebecca Wood, of the Alzheimer's Research Trust, stressed that people would need to eat a lot of curry - over 100g of turmeric curry powder - to get a clinical dose of curcumin.
She said: "Professor Doraiswamy's unpublished research applies only to animal models; his hypothesis has not been confirmed in human clinical trials.
"We look forward to the results of the human curcumin trial at UCLA."
Dr Susanne Sorensen, of the Alzheimer's Society, said: "Indian communities that regularly eat curcumin have a surprisingly low incidence of Alzheimer's disease but we don't yet know why.
"Alzheimer's Society is keen to explore the potential benefits of curcumin in protecting the brain and we are conducting our own research into this area.
"A cheap, accessible and safe treatment could transform the quality of life of thousands of people with the condition."

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