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zoom RSS 妊娠中はコーヒー1日2杯までに/英国 FSA

<<   作成日時 : 2008/11/03 19:34   >>

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 食品標準庁FSAは妊娠した女性のカフェイン摂取量を1日最大300mgから200mgへと下げ、コーヒーなら2杯、紅茶なら4杯に相当する。カフェインと低出生体重の関連がわかった。低出生体重の子どもは、心臓病や糖尿病などの健康問題とも関連している。
 最新の研究では、妊娠中の少量のアルコールは生まれてくる男子の問題行動と多動のリスクを軽減するというが、現時点では妊娠中のアルコールは推奨していない。
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カフェインにより流産のリスクが増大
http://kurie.at.webry.info/200801/article_40.html
コーヒー中毒に注意
http://kurie.at.webry.info/200708/article_23.html
コーヒールンバの科学的証明?
http://kurie.at.webry.info/200708/article_15.html
コーヒーが多発性硬化症を予防する可能性
http://kurie.at.webry.info/200807/article_13.html
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Page last updated at 23:13 GMT, Sunday, 2 November 2008
Cut caffeine, pregnant women told
http://news.bbc.co.uk/2/hi/health/7705319.stm

画像Pregnant women should cut their caffeine intake and drink no more than two cups of coffee or four cups of tea a day, a government agency has advised.

The Food Standards Agency (FSA) has lowered its recommended levels of the stimulant from a maximum of 300mg a day to 200mg - a reduction of a third.
It follows research by Leicester and Leeds universities linking caffeine to babies born with low birth weight.
The study will be published in the British Medical Journal this week.
Children born with a low birth weight are more likely to suffer health problems like heart disease and diabetes.

I want to reassure women that if you're pregnant and have been following the previous advice, the risk is likely to be small
Andrew Wadge
FSA chief scientist

The advice means women should stick to a maximum of two average-sized cups of coffee per day - although those who have been drinking three cups have been told not to panic.
The FSA's chief scientist Andrew Wadge said: "This is new advice but these are not new risks.
"I want to reassure women that if you're pregnant and have been following the previous advice, the risk is likely to be small."
The FSA guidance means women should limit themselves to three or four cups of tea a day and watch their intake of cola, chocolate and energy drinks.
Drinks bought from coffee shops may be far higher than the FSA estimates for the average-sized home-made cup.
The university study which prompted the revised guidance involved 2,500 pregnant women.
The new guidance follows another study suggesting drinking lightly during pregnancy cut the risk of problem behaviour and hyperactivity in boys.
The University College London report found boys born to light drinkers did better on vocabulary tests than those born to mothers who abstained completely during pregnancy.
Current medical advice is that women should avoid alcohol while pregnant or trying to conceive.

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Published 3 November 2008, doi:10.1136/bmj.a2332
Cite this as: BMJ 2008;337:a2332
Research
Maternal caffeine intake during pregnancy and risk of fetal growth restriction: a large prospective observational study

CARE Study Group

Correspondence to: Justin C Konje, Department of Cancer Studies and Molecular Medicine, University of Leicester, Leicester LE2 7LX, jck4@le.ac.uk. Alternative correspondence: Janet E Cade, Centre for Epidemiology and Biostatistics, University of Leeds, Leeds LS2 9JT, j.e.cade@leeds.ac.uk
Abstract

Objective To examine the association of maternal caffeine intake with fetal growth restriction.

Design Prospective longitudinal observational study.

Setting Two large UK hospital maternity units.

Participants 2635 low risk pregnant women recruited between 8-12 weeks of pregnancy.

Investigations Quantification of total caffeine intake from 4 weeks before conception and throughout pregnancy was undertaken with a validated caffeine assessment tool. Caffeine half life (proxy for clearance) was determined by measuring caffeine in saliva after a caffeine challenge. Smoking and alcohol were assessed by self reported status and by measuring salivary cotinine concentrations.

Main outcome measures Fetal growth restriction, as defined by customised birth weight centile, adjusted for alcohol intake and salivary cotinine concentrations.

Results Caffeine consumption throughout pregnancy was associated with an increased risk of fetal growth restriction (odds ratios 1.2 (95% CI 0.9 to 1.6) for 100-199 mg/day, 1.5 (1.1 to 2.1) for 200-299 mg/day, and 1.4 (1.0 to 2.0) for >300 mg/day compared with <100 mg/day; test for trend P<0.001). Mean caffeine consumption decreased in the first trimester and increased in the third. The association between caffeine and fetal growth restriction was stronger in women with a faster compared to a slower caffeine clearance (test for interaction, P=0.06).

Conclusions Caffeine consumption during pregnancy was associated with an increased risk of fetal growth restriction and this association continued throughout pregnancy. Sensible advice would be to reduce caffeine intake before conception and throughout pregnancy.
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妊娠中はコーヒー1日2杯までに/英国 FSA 医師の一分/BIGLOBEウェブリブログ
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