医師の一分

アクセスカウンタ

zoom RSS 抗うつ剤は服用後迅速に効果を表す

<<   作成日時 : 2009/11/26 01:02   >>

なるほど(納得、参考になった、ヘー) ブログ気持玉 1 / トラックバック 0 / コメント 0

 従来の考えとは異なり、抗うつ剤を服用後直ちに気分を昂揚させる作用は出現するとのオックスフォード大の研究報告。患者は治療効果は数ヶ月も気づかないが潜在的に作用している。服薬後数時間以内で急速に効果が出現しネガティブな考え方が変わる。ネガティブな思考サイクルを壊す会話療法が手助けとなる理由となっているかもしれない。
 気分や不安が良くなっていないと感じても、ネガティブな考えには効いているという。
----------------------------------------------------
Page last updated at 00:37 GMT, Monday, 26 October 2009
Antidepressants 'work instantly'
http://news.bbc.co.uk/2/hi/health/8304782.stm
By Michelle Roberts
Health reporter, BBC News

画像Antidepressant
The drugs appear to promote positive thinking

Antidepressants get to work immediately to lift mood, contrary to current belief, UK researchers say.

Although patients may not notice the effects until months into the therapy, the team say they work subconsciously.

The action is rapid, beginning within hours of taking the drugs, and changes negative thoughts, according to the Oxford University researchers.

These subtle, positive cues may add up over time to lift the depression, the American Journal of Psychiatry reports.

It may also explain why talking therapies designed to break negative thought cycles can also help.

We found the antidepressants target the negative thoughts before the patient is aware of any change in feeling subjectively
Lead researcher Dr Harmer

Psychiatrist Dr Catherine Harmer and her team at Oxford University closely studied the reactions of 33 depressed patients and 31 healthy controls given either an antidepressant or a dummy drug.

The depressed patients who took the active drug showed positive improvements in three specific measures within three hours of taking them.

These patients were more likely to think about themselves in a positive light, rather than dwelling on their bad points, the researchers said.

They were also more likely to see the positive in others.

For example, if they saw a grumpy person they no longer internalised this to think that they must have done something wrong to upset the person.

New drugs

This was despite feeling no improvement in mood or anxiety.

Dr Harmer said: "We found the antidepressants target the negative thoughts before the patient is aware of any change in feeling subjectively.

"Over time, this will affect our mood and how we feel because we are receiving more positive information."

She said the findings could help scientists looking for new drugs to treat depression.

Dr Michael Thase, a psychiatrist from the University of Pennsylvania, said the findings challenged conventional wisdoms and were potentially "paradigm-changing".

But he said much more research was needed.

"The highest research priority is to confirm that the rapid effects observed in this study are predictive of eventual clinical benefit."

He said it was possible that switching off the negative thoughts was a crucial part of the therapy.

Alternatively, it might merely be a sign that the drug was beginning to work at the cell level in the brain.

Paul Farmer, chief executive of Mind, said: "This research may contribute to our understanding of how our bodies respond to antidepressants, but the changes recorded can't always be felt by patients and it can be some weeks before they begin to feel the symptoms of depression easing.

"We must also remember that the side-effects of medication can often be felt straight away long before the benefits really kick in, and this will always affect people's experiences in the initial stages of treatment."

----------------------------------------------------
Am J Psychiatry 2009; 166:1178-1184
(published online September 15, 2009; doi: 10.1176/appi.ajp.2009.09020149)
(c) 2009 American Psychiatric Association

Effect of Acute Antidepressant Administration on Negative Affective Bias in Depressed Patients

Catherine J. Harmer, D.Phil., Ursula O’Sullivan, M.B.Ch.B., F.R.A.N.Z.C.P., Elisa Favaron, M.D., Rachel Massey-Chase, B.A., Rachael Ayres, B.A., Andrea Reinecke, Dipl.Psych., Dr.rer.nat., Guy M. Goodwin, D.Phil., F.R.C.Psych., and Philip J. Cowen, M.D., F.R.C.Psych.

OBJECTIVE: Acute administration of an antidepressant increases positive affective processing in healthy volunteers, an effect that may be relevant to the therapeutic actions of these medications. The authors investigated whether this effect is apparent in depressed patients early in treatment, prior to changes in mood and symptoms. METHOD: In a double-blind, placebo-controlled, between-groups randomized design, the authors examined the effect of a single 4-mg dose of the norepinephrine reuptake inhibitor reboxetine on emotional processing. Thirty-three depressed patients were recruited through primary care clinics and the community and matched to 31 healthy comparison subjects. Three hours after dosing, participants were given a battery of emotional processing tasks comprising facial expression recognition, emotional categorization, and memory. Ratings of mood, anxiety, and side effects were also obtained before and after treatment. RESULTS: Depressed patients who received placebo showed reduced recognition of positive facial expressions, decreased speed in responding to positive self-relevant personality adjectives, and reduced memory for this positive information compared to healthy volunteers receiving placebo. However, this effect was reversed in patients who received a single dose of reboxetine, despite the absence of changes in subjective ratings of mood or anxiety. CONCLUSIONS: Antidepressant drug administration modulates emotional processing in depressed patients very early in treatment, before changes occur in mood and symptoms. This effect may ameliorate the negative biases in information processing that characterize mood and anxiety disorders. It also suggests a mechanism of action compatible with cognitive theories of depression.



テーマ

関連テーマ 一覧


月別リンク

ブログ気持玉

クリックして気持ちを伝えよう!
ログインしてクリックすれば、自分のブログへのリンクが付きます。
→ログインへ
気持玉数 : 1
なるほど(納得、参考になった、ヘー)

トラックバック(0件)

タイトル (本文) ブログ名/日時

トラックバック用URL help


自分のブログにトラックバック記事作成(会員用) help

タイトル
本 文

コメント(0件)

内 容 ニックネーム/日時

コメントする help

ニックネーム
本 文
抗うつ剤は服用後迅速に効果を表す 医師の一分/BIGLOBEウェブリブログ
文字サイズ:       閉じる