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zoom RSS 多発性硬化症は脳静脈還流異常による?

<<   作成日時 : 2009/12/03 20:34   >>

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 多発性硬化症MSは脳血液の還流をおこなう静脈の遮断により引きおこされるとする斬新な仮説を米国バッファロー大の研究者が検証している。MSの90%が静脈の狭窄により起こると主張するイタリアの研究者パオロ・ザンボーニ博士の仕事に好奇心をそそられた。脳スキャンにより認められる還流異常が脳を障害してMSを発症するという。すでに5人の患者の狭窄を広げる治療を施行した。
 米国チームは治療の前に以前の研究の追試をしようとしている。1,100人の患者と600人の対象者を募集している。MSは中枢神経の慢性の自己免疫反応による炎症状態により起こるとされてきた。超音波により頸部と脳の静脈の異常を見つける計画だが、もしMSが「慢性脳脊髄静脈不全」なら、病気の認識を変える必要がある。
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Page last updated at 00:07 GMT, Friday, 27 November 2009
Multiple sclerosis 'blood blockage theory' tested
http://news.bbc.co.uk/2/hi/health/8374980.stm
By Michelle Roberts
Health reporter, BBC News

画像Brain scan of MS
The answer may lie with blood flow

US scientists are testing a radical new theory that multiple sclerosis (MS) is caused by blockages in the veins that drain the brain.

The University of Buffalo team were intrigued by the work of Italian researcher Dr Paolo Zamboni who claims 90% of MS is caused by narrowed veins.
He says the restricted drainage, visible on scans, injures the brain leading to MS.
He has already widened the blockages in a handful of patients.
The US team want to replicate his earlier work before treating patients.
Experts welcomed the research saying it was important to confirm the basic science before evaluating any therapy.
MS is a long-term inflammatory condition of the central nervous system which affects the transfer of messages from the nervous system to the rest of the body.

This is not something patients can expect as a treatment now. This is experimental work and is being tested
A spokeswoman for the MS Society

The Buffalo team, led by Dr Robert Zivadinov, plan to recruit 1,100 patients with MS and 600 other volunteers as controls who are either healthy or have neurological diseases other than MS.
Using Doppler ultrasound, they will scan the patients to see if they can find any blockages within the veins of the neck and brain.
If they can prove Dr Zamboni's theory of "chronic cerebrospinal venous insufficiency", they say it will change our understanding of MS.

Rewriting science
Margaret Paroski, who is chief medical officer at Kaleida Health, where the Buffalo researchers are based, said the work could overturn prevailing wisdom that the damage in MS is predominantly the result of abnormal immune responses.
"When I was in medical school, we thought peptic ulcer disease was due to stress. We now know that 80% of cases are due to a bacterial infection.

I found the evidence of narrowing - narrowing of the veins just in MS patients
Dr Zamboni

"Dr Zivadinov's work may lead to a whole different way of thinking about MS."

Dr Zamboni, of the University of Ferrara, believes the blockages are the cause rather than the consequence of MS and that they allow iron from the blood to leak into the brain tissue, where it causes damage.
He has performed procedures similar to angioplasty to unblock the veins and get the blood flowing normally again.
He claims this "liberation procedure" can alleviate many of the symptoms of MS and is due to publish his findings in the Journal of Vascular Surgery.
In an interview with CTV News in Canada he said: "I found the evidence of narrowing - narrowing of the veins just in MS patients.
"I'm fully convinced that this is very, very important for people."

Early days
Kevin Lipp, an MS patient from the US, has been symptom-free since being treated by Dr Zamboni.
He said: "It's only been 10 months. If nothing happens in the next two to three years, we'll know it's working."
The BBC has heard anecdotally of other surgeons in Europe testing out the same treatment.
The MS Society said more research was needed to see if this was an avenue that should be explored further.
"This is not something patients can expect as a treatment now. This is experimental work and is being tested. We need to know more about its safety and effectiveness."
Helen Yates, of the MS Resource Centre, said: "There is no doubt that this area warrants a great deal more study.
"This could represent a completely novel approach to MS research which, if proven to be relevant, could be a "sea change" in the understanding of the mechanisms involved in the condition."

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J Cereb Blood Flow Metab. 2009 Sep 2. [Epub ahead of print]
Anomalous venous blood flow and iron deposition in multiple sclerosis.

Singh AV, Zamboni P.

Department of Physics, European School of Molecular Medicine (SEMM), IFOM-IEO Campus, Centro Interdisciplinare Materiali e Interfacce Nanostrutturati (CIMAINA), University of Milan, Milan, Italy.

Multiple sclerosis (MS) is primarily an autoimmune disorder of unknown origin. This review focuses iron overload and oxidative stress as surrounding cause that leads to immunomodulation in chronic MS. Iron overload has been demonstrated in MS lesions, as a feature common with other neurodegenerative disorders. However, the recent description of chronic cerebrospinal venous insufficiency (CCSVI) associated to MS, with significant anomalies in cerebral venous outflow hemodynamics, permit to propose a parallel with chronic venous disorders (CVDs) in the mechanism of iron deposition. Abnormal cerebral venous reflux is peculiar to MS, and was not found in a miscellaneous of patients affected by other neurodegenerative disorders characterized by iron stores, such as Parkinson's, Alzheimer's, amyotrophic lateral sclerosis. Several recently published studies support the hypothesis that MS progresses along the venous vasculature. The peculiarity of CCSVI-related cerebral venous blood flow disturbances, together with the histology of the perivenous spaces and recent findings from advanced magnetic resonance imaging techniques, support the hypothesis that iron deposits in MS are a consequence of altered cerebral venous return and chronic insufficient venous drainage.Journal of Cerebral Blood Flow & Metabolism advance online publication, 2 September 2009; doi:10.1038/jcbfm.2009.180.

PMID: 19724286 [PubMed - as supplied by publisher]

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多発性硬化症は脳静脈還流異常による? 医師の一分/BIGLOBEウェブリブログ
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