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zoom RSS 社会的地位と線条体ドーパミンが関連

<<   作成日時 : 2010/02/09 01:12   >>

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 新たな研究によれば、社会的地位や社会的支持が脳内線条体のドーパミン受容体D2/D3密度と関連しているという。報酬や動機付けの主要な役割を果たしている。大きな社会的地位を得る人は線条体のドーパミン作用点が多いために人生に価値と刺激を得やすい可能性がある。
 また、以前の研究では社会的地位の低い人は薬物乱用リスクが高いことが示唆されている。
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Dopamine Levels in Brain May Determine Social Status
Having more of it linked to greater social support, researchers say
-- Robert Preidt
http://health.msn.com/health-topics/articlepage.aspx?cp-documentid=100253990

Having more of it linked to greater social support, researchers say.

FRIDAY, Feb. 5 (HealthDay News) -- The makeup of your brain may influence your social standing, a new study suggests.

Researchers conducted PET scans of the brains of healthy volunteers and assessed their levels of social status and social support. The results suggest that social status and social support are associated with the density of dopamine D2/D3 receptors in an area of the brain called the striatum, which plays a major role in reward and motivation.

"We showed that low levels of dopamine receptors were associated with low social status and that high levels of dopamine receptors were associated with higher social status. The same type of association was seen with the volunteer's reports of social support they experience from their friends, family or significant other," Dr. Diana Martinez, of the New York State Psychiatric Institute, said in a news release.

People who achieve greater social status are more likely to find life rewarding and stimulating because they have more targets for dopamine to act upon within the striatum, Martinez explained. Dopamine is a chemical that transmits signals between brain cells.

The study was published in the Feb. 1 issue of Biological Psychiatry.

"These data shed interesting light into the drive to achieve social status, a basic social process," said journal editor Dr. John Krystal. "It would make sense that people who had higher levels of D2 receptors, i.e., were more highly motivated and engaged by social situations, would be high achievers and would have higher levels of social support."

The study also may help improve understanding about why certain people are more likely to abuse alcohol and drugs. Previous studies have suggested that lower levels of social status and social support contribute to the risk of substance abuse.

More information

The U.S. National Institute of Alcohol Abuse and Alcoholism has more about alcohol abuse and alcoholism.
SOURCE: Biological Psychiatry, news release, Feb. 3, 2010

Copyright @2010 HealthDay. All Rights Reserved.

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Am J Psychiatry. 2000 Mar;157(3):457-9.
Low dopamine D(2) receptor binding potential in social phobia.

Schneier FR, Liebowitz MR, Abi-Dargham A, Zea-Ponce Y, Lin SH, Laruelle M.

Anxiety Disorders Clinic and the Brain Imaging Division, New York State Psychiatric Institute, New York 10032, USA. frs1@columbia.edu

Comment in:

* Am J Psychiatry. 2001 Feb;158(2):327-8.

OBJECTIVE: This study compared dopamine D(2) receptor binding potential in patients with social phobia and healthy comparison subjects. METHOD: Dopamine D(2) receptor binding potential was assessed in 10 unmedicated subjects with generalized social phobia and no significant lifetime psychiatric comorbidity and 10 healthy comparison subjects matched for age and sex. Binding potential was measured in the striatum by using single photon emission computerized tomography and constant infusion of the D(2) receptor radiotracer [(123)I]iodobenzamide ([(123)I]IBZM). RESULTS: Mean D(2) receptor binding potential was significantly lower in the subjects with social phobia than in the comparison subjects. Within the social phobia group, there was a nonsignificant correlation of binding potential with the Liebowitz Social Anxiety Scale score. CONCLUSIONS: Generalized social phobia may be associated with low binding of [(123)I]IBZM to D(2) receptors in the striatum.

PMID: 10698826 [PubMed - indexed for MEDLINE]

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