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<<   作成日時 : 2010/04/30 20:54   >>

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 いつどこで誕生したかが多発性硬化症の発症リスクに影響する。南半球で初夏に生まれた子供は初冬に生まれた子どもより多発性硬化症になりやすいという。同様なパターンは北半球では逆にみられる。
 妊娠中に日光に浴びていないと発症率が高くなる可能性がある。ビタミンDが低いと発症しやすくなり、日光はビタミンDを上昇させる。1920-1950年にオーストラリアで生まれ、多発性硬化症を発症した子どもについてデータを分析した。
 南半球の初夏にあたる11-12月生まれの子どもは、初冬である5−6月生まれの子どもより約30%発症率が高かった。母親が出産前5〜9ヶ月に日光の曝露が少ないと子どもが発症しやすくなる。
 母親に対してビタミンDを補充する必要があるかもしれない。
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http://kurie.at.webry.info/201002/article_10.html
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http://kurie.at.webry.info/200902/article_19.html
日光浴が多発性硬化症を予防する
http://kurie.at.webry.info/200707/article_59.html
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Sunlight May Play Role in Multiple Sclerosis Risk
Adequate vitamin D in months before birth could be key, Australian study suggests
-- Randy Dotinga
http://health.msn.com/health-topics/neurological-cognitive-health/articlepage.aspx?cp-documentid=100257665

Adequate vitamin D in months before birth could be key, Australian study suggests.

THURSDAY, April 29 (HealthDay News) -- When and where people are born may affect their odds of developing multiple sclerosis, according to researchers who found that children born in the early summer months in the Southern Hemisphere are more likely to develop multiple sclerosis than those born in early winter.

A similar pattern has been found in the Northern Hemisphere, where the summer and winter months are the reverse of those in the Southern Hemisphere. The researchers think the higher disease rates may have something to do with the children's mothers getting less exposure to sunlight during pregnancy.

Scientists have linked low vitamin D levels to higher rates of multiple sclerosis, and sunlight boosts vitamin D levels.

In the new study, published online April 29 in BMJ, Anne-Louise Ponsonby, of the Murdoch Children's Research Institute at Royal Children's Hospital in Melbourne, and her colleagues analyzed data on children with multiple sclerosis born in Australia from 1920 to 1950. They tried to find links to the levels of sunlight in the regions in which the mothers lived.

The risk was about 30 percent higher for those born in November and December, which are early summer months in the Southern Hemisphere, compared with those born in the early winter months of May and June, the study found. Babies were more likely to have multiple sclerosis if their mothers had low exposure to sunlight from five to nine months before giving birth.

The study authors wrote that researchers need to analyze the idea of giving vitamin D supplements to pregnant mothers to help prevent multiple sclerosis.

More information

For more on multiple sclerosis, visit the National Multiple Sclerosis Society.
SOURCE: BMJ, news release, April 29, 2010

Copyright @2010 HealthDay. All Rights Reserved.

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Published 29 April 2010, doi:10.1136/bmj.c1640
Cite this as: BMJ 2010;340:c1640
Research
Low maternal exposure to ultraviolet radiation in pregnancy, month of birth, and risk of multiple sclerosis in offspring: longitudinal analysis

Judith Staples, student1, Anne-Louise Ponsonby, professor2, Lynette Lim, biostatistician1

1 National Centre for Epidemiology and Population Health, Australian National University, Canberra, Australia, 2 Murdoch Childrens Research Institute, Royal Children’s Hospital, Melbourne, Victoria, Australia

Objectives To investigate the distribution of month of birth in people with multiple sclerosis in Australia. To use the large regional and seasonal variation in ambient ultraviolet radiation in Australia to explore the association between exposure to ultraviolet radiation during pregnancy and subsequent risk of multiple sclerosis in offspring.

Design Data were gathered on birth month and year (1920-1950), sex, and state of birth for all patients surveyed in 1981 in Queensland, Western Australia, New South Wales (including Australian Capital Territory), South Australia, and Hobart (Tasmania). Population denominators were derived from the 1981 census and supplementary birth registration data. A variable for exposure to ambient ultraviolet radiation "at birth" was generated from monthly averages of daily total ambient ultraviolet radiation for each region. Negative binomial regression models were used to investigate exposure to ambient ultraviolet radiation at birth and at various intervals before birth.

Setting Patient data from multiple sclerosis prevalence surveys carried out in 1981; 1981 Australian census (giving the total number of people born in Australia and still alive and living in Australia in 1981 by year of birth 1920-50); supplementary Australian birth registration data covering the same birth years by month and state.

Participants 1524 patients with multiple sclerosis born in Australia 1920-50 from total population of 2 468 779.

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