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zoom RSS BPAが男性のテストステロンレベルを増加させる

<<   作成日時 : 2010/09/27 23:53   >>

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 プラスチックに含まれる化学薬品が男性のテストステロンレベルを増加させると報告があった。ビスフェノールAが多い人は、テストステロンを上昇させる。レジスターのレシートにも全重量の3%のBPAが含まれているとの発表も最近あった。
 研究では715人の成人の尿中BPAを調べた。1日あたりの平均BPA曝露量は5μg以上であった。男性では尿中のBPA排泄量が高い人ほど総テストステロン濃度が高かった。
 BPAはプラスチック容器やいくつかの哺乳瓶からも見つかっている。人のホルモンレベルを変えるため、「内分泌攪乱物質」と呼ばれている。ホルモン様の効果は胎児や乳幼児の発育にとって特に危険な可能性がある。環境保護庁は、今年初めにBPAを問題化学物質リストに載せた。

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Chemicals in plastics can increase testosterone in men
August 25, 2010|4:33 p.m

http://www.latimes.com/health/boostershots/la-heb-bisphenol-20100825,0,6542199.story

画像A chemical found in plastics has been shown to increase testosterone levels in men, British researchers reported on Wednesday. They found that men who had high levels of the chemical bisphenol A also had higher testosterone levels compared to men with lower levels of the chemical in their bodies.

The chemical, also known as BPA, is commonly found in plastic products around the world. The new study comes on the heels of research released earlier this month that found high amounts of BPA are present in everyday cash register receipts, as much as 3% of the total weight of the receipt.

In the new study, researchers analyzed urine samples of 715 adults. The average BPA daily exposure was more than five micrograms per day -- which is similar to what has been found in other surveys. The higher the daily BPA excretion in urine, the higher the total testosterone concentrations in men.


"The results are important because they provide a first report in a large-scale human population of associations between elevated exposure to BPA and alterations in circulating hormone levels," the authors wrote. "They also illustrate that the extent of exposure to BPA is similar in this European mixed urban and rural population to exposures seen in the general adult population of the USA."

BPA is found in plastic food and drink containers, even some baby bottles. It may leach out of the plastic into food. The chemical is called an "endocrine disruptor" because it alters human hormone levels, which can contribute to illness and disease. The hormonelike effects of the chemical may be especially dangerous to infants or during fetal development. The Environmental Protection Agency announced earlier this year that it will add BPA to its ''chemical concern'' list due to potential environmental effects.

The study was led by researchers at the Peninsula Medical School and the University of Exeter and was published in the journal Environmental Health Perspectives.

-- Shari Roan / Los Angeles Times

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Daily Bisphenol A Excretion and Associations with Sex Hormone Concentrations: Results from the InCHIANTI Adult Population Study

Tamara Galloway, Riccardo Cipelli, Jack Guralnick, Luigi Ferrucci, Stefania Bandinelli, Anna Maria Corsi, Cathryn Money, Paul McCormack, David Melzer

Abstract Top

Background: Bisphenol A is a high production volume chemical widely used in food and drinks packaging. Numerous studies demonstrate that BPA can alter endocrine function in animals, yet human studies remain limited.

Objective: To estimate daily excretion of BPA in adults and to examine hypothesized associations with serum estrogen and testosterone concentrations.

Design, setting and participants: Cross-sectional analysis of associations in the InCHIANTI study, an Italian population sample. Included were 715 adults aged 20 through 74 years. BPA concentrations were measured by liquid chromatography mass spectrometry (LC-MS) in 24 hour urine samples.

Main outcome measures: serum concentrations of total testosterone and 17 beta-estradiol.

Results: Geometric mean urinary BPA concentration was 3.59 ng/ml (95% CI 3.42 to 3.77), and mean excretion was 5.63 ?g/day (5th population percentile 2.1 ?g/day , 95th percentile 16.4 ?g/day). Higher excretion was found in men, younger respondents and with increasing waist circumference (p=0.013) and weight (p=0.003).

Daily BPA excretion was associated with total testosterone concentrations in men, in age and study site adjusted models (p= 0.044) and in models adjusted additionally for smoking, measures of obesity and urinary creatinine concentrations (β=0.046 CI 0.015 to 0.076, p=0.004). There were no associations with the other serum measures. There were no associations with the primary outcomes in women, but there was an association between BPA and SHBG concentrations in the 60 pre-menopausal women.

Conclusion: Higher BPA exposure may be associated with endocrine changes in men. The mechanisms involved in the observed cross-sectional association with total testosterone concentrations need to be clarified.

Citation: Galloway T, Cipelli R, Guralnick J, Ferrucci L, Bandinelli S, Corsi AM, et al. 2010. Daily Bisphenol A Excretion and Associations with Sex Hormone Concentrations: Results from the InCHIANTI Adult Population Study. Environ Health Perspect :-. doi:10.1289/ehp.1002367

Received: 29 April 2010; Accepted: 20 August 2010; Online: 25 August 2010

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