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zoom RSS レジ係の妊婦からビスフェノールA/BPA

<<   作成日時 : 2010/10/10 23:46   >>

なるほど(納得、参考になった、ヘー) ブログ気持玉 1 / トラックバック 0 / コメント 0

画像 ビスフェノールAは、多くの製品を作るために使われ、ポリカーボネートプラスチックの中に見られる化学薬品である。エストロゲン類似作用をするため、特に出世前の曝露が有害とされる。シンシナティの386人の妊婦の尿でBPAを検査したところ、90%から検出された。高卒以下の教育歴の女性で高濃度にみられたが、社会経済的な因子には関係なかった。最も高濃度なのはレジ係として働いている女性であった。8月に発表された研究ではレジ・レシートの重量の3%がBPAであった。最も低濃度だったのは、教育や工場で働く女性であった。タバコの煙に曝された女性は高く、菜食主義者は低かった。
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BPAが男性のテストステロンレベルを増加させる
http://kurie.at.webry.info/201009/article_20.html
BPAの健康への影響調査研究に3000万ドルを投入/米国 FDA 哺乳瓶
http://kurie.at.webry.info/201001/article_17.html
プラスチック哺乳瓶の安全性に残る疑問/米国
http://kurie.at.webry.info/200809/article_6.html
FDA プラスチック製品のビスフェノールAは安全との報告/米国
http://kurie.at.webry.info/200808/article_35.html
プラスチック製品のビスフェノールAを有毒の表示に/カナダ
http://kurie.at.webry.info/200804/article_29.html
プラスチック製の水筒や哺乳瓶の安全性に疑問
http://kurie.at.webry.info/200804/article_24.html
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Levels of worrisome chemical higher in female cashiers
http://www.latimes.com/health/boostershots/la-heb-bisphenol-20101008,0,5165937.story

October 8, 2010|10:18 a.m.

Bisphenol A is a chemical found in polycarbonate plastic used to make numerous consumer products. In recent years, studies have suggested that high levels of the chemical stored in the body can lead to adverse health effects. Prenatal exposure is thought to be particularly harmful because the chemical can mimic estrogen. High levels in pregnancy have been linked in some studies to an increased risk of obesity and behavioral problems in children.

Research published Friday indicates that bisphenol A levels in pregnant women vary widely.
Scientists examined BPA levels in urine samples from 386 pregnant women in Cincinnati. About 90% of the women had detectable levels of bisphenol A. Higher concentrations were found in women with education levels below a high school graduation, but socioeconomic factors did not seem to affect exposures otherwise.

The highest levels were found in women who worked as cashiers compared with women working in other occupations. A study published in August found bisphenol A content was present in cash register receipts and made up 3% of the total weight of the receipt. This association, however, "should be interpreted cautiously," the authors of the new study wrote, because the data were based on readings from only 17 women. Further research is needed on this link in order to advise pregnant cashiers on whether they should wear gloves or masks at work to prevent exposure. The lowest levels of BPA were found among women who reported working in teaching or industrial occupations.

The study also found that pregnant women exposed to tobacco smoke had higher levels of bisphenol A as well as women who reported eating more canned vegetables and women exposed to phthalate-containing products, such as vinyl flooring and plastic containers. Vegetarians had lower levels of BPA concentrations compared with non-vegetarians, but only five women in the study reported being vegetarians.

The study was published online Friday in Environmental Health Perspectives.

-- Shari Roan / Los Angeles Times

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Variability and Predictors of Urinary Bisphenol A Concentrations during Pregnancy

Joe M. Braun, Amy E. Kalkbrenner, Antonia M. Calafat, John T. Bernert, Xiaoyun Ye, Manori J. Silva, Dana Boyd Barr, Sheela Sathyanarayana, Bruce P. Lanphear

Abstract

Background: Prenatal bisphenol A (BPA) exposure may be associated with developmental toxicity, but few studies have examined the variability and predictors of urinary BPA concentrations during pregnancy.

Objective: To estimate the variability and predictors of serial urinary BPA concentrations taken during pregnancy.

Methods: We measured BPA concentrations during pregnancy and at birth in three spot urine samples from 389 women. We calculated the intraclass correlation coefficient (ICC) to assess BPA variability and estimated associations between log10-transformed urinary BPA concentrations and demographic, occupational, dietary, and environmental factors using mixed models.

Results: Geometric mean (GM) creatinine-standardized concentrations (μg/g) were 1.7 (16 weeks), 2.0 (26 weeks), and 2.0 (birth). Creatinine-standardized BPA concentrations exhibited low reproducibility (ICC: 0.11). By occupation, cashiers had the highest BPA concentrations (GM: 2.8 μg/g). Consuming canned vegetables at least once a day was associated with higher BPA concentrations (GM: 2.3 μg/g) compared to those consuming no canned vegetables (GM: 1.6 μg/g). BPA concentrations did not vary by consumption of fresh fruits and vegetables, canned fruit, or store-bough fresh and frozen fish. Urinary high molecular weight phthalate and serum tobacco smoke metabolite concentrations were positively associated with BPA concentrations.

Conclusions: These results suggest that numerous sources of BPA exposure during pregnancy exist. Etiological studies may need to measure urinary BPA concentrations more than once during pregnancy and adjust for phthalates and tobacco smoke exposures.

Citation: Braun JM, Kalkbrenner AE, Calafat AM, Bernert JT, Ye X, Silva MJ, et al. . 2010. Variability and Predictors of Urinary Bisphenol A Concentrations during Pregnancy. Environ Health Perspect :-. doi:10.1289/ehp.1002366

Received: 29 April 2010; Accepted: 27 September 2010; Online: 08 October 2010

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